Molecular structure of Thioetheramide PC, CAS Number: 116457-99-9
Thioetheramide PC (CAS 116457-99-9)
Alternate Names:
Thioetheramide-phosphorylcholine; 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine
Application:
Thioetheramide PC is a reversible inhibitor of secretory phospholipase A2 (sPLA2)
CAS Number:
116457-99-9
Purity:
≥98%
Molecular Weight:
735.1
Molecular Formula:
C40H83N2O5PS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Thioetheramide PC is a reversible inhibitor of secretory phospholipase A2 (sPLA2) that binds to both the catalytic site and activator site of sPLA2. The PLA2 enzyme is found Chinese cobra snake venom and it binds more firmly to the activator site of the enzyme in comparison to the catalytic site. Research indicates that Thioetheramide PCs ability to bind to both sites may be due to the phophoslipase activation that occurs with low concentrations of the compound, which does not inhibit the enzyme.
Thioetheramide PC (CAS 116457-99-9) References
- Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | Beck-Speier, I., et al. 2003. Prostaglandins Other Lipid Mediat. 71: 217-34. PMID: 14518563
- Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. | Qi, HY. and Shelhamer, JH. 2005. J Biol Chem. 280: 38969-75. PMID: 16176925
- Cytosolic phospholipase A2 group IVA influence on GM-CSF expression in human lung cells: a pilot study. | Sokolowska, M., et al. 2010. Med Sci Monit. 16: BR300-6. PMID: 20802406
- Interfacial catalysis: the mechanism of phospholipase A2. | Scott, DL., et al. 1990. Science. 250: 1541-6. PMID: 2274785
- The interaction of phospholipase A2 with phospholipid analogues and inhibitors. | Yu, L., et al. 1990. J Biol Chem. 265: 2657-64. PMID: 2303420
- Beneficial effects of Lactobacillus rhamnosus hsryfm 1301 fermented milk on rats with nonalcoholic fatty liver disease. | Chen, D., et al. 2023. J Dairy Sci. 106: 1533-1548. PMID: 36710180
- Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2. | Hope, WC., et al. 1993. Agents Actions. 39 Spec No: C39-42. PMID: 8273580
- Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. | Plesniak, LA., et al. 1993. Biochemistry. 32: 5009-16. PMID: 8494876
Inhibitor of:
sPLA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thioetheramide PC, 5 mg | sc-202840 | 5 mg | $64.00 | |||
Thioetheramide PC, 25 mg | sc-202840A | 25 mg | $321.00 |