SPIN3 inhibitors belong to a class of chemical compounds designed to selectively interact with a specific protein known as SPIN3, which is an acronym from its more technical nomenclature. The SPIN3 protein is part of a larger family of proteins that play crucial roles in various biological processes at the molecular level, including the regulation of gene expression, intracellular signaling pathways, and protein-protein interactions. These proteins often have distinct structural domains that allow them to bind to other molecules, thereby influencing cellular functions. The inhibitors targeting SPIN3 are crafted to bind with high affinity to this protein, thereby modulating its activity. The design of SPIN3 inhibitors is based on an intricate understanding of the protein's structure and the key functional domains that are critical for its activity.
The development of SPIN3 inhibitors involves the application of various fields of chemistry, including medicinal chemistry, organic chemistry, and computational chemistry, to identify and optimize molecules that can interact with SPIN3 protein effectively. This process typically starts with the identification of a lead compound, which exhibits the desired interaction with the protein. Subsequent optimization steps involve tweaking the chemical structure of the lead compound to enhance its binding properties, increase its selectivity for SPIN3, and improve its overall molecular characteristics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
PI3K inhibitor that prevents Akt phosphorylation. If SPIN3 has any interaction with PI3K or downstream components, LY294002 can potentially modulate its function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
MEK inhibitor targeting the ERK pathway. If SPIN3 function or expression is influenced by the ERK pathway, this inhibitor can potentially alter this modulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor. If SPIN3 is influenced by the p38 MAPK pathway, SB203580 can have an effect on its function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor, potentially influencing any downstream effects or modulation of SPIN3 linked to JNK signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
ROCK inhibitor. If SPIN3 is associated with pathways modulated by ROCK, Y-27632 can potentially alter its function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor, potentially impacting SPIN3 if it has any association with the PI3K pathway. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor. If SPIN3 is involved in mTOR signaling, its function can be affected by Rapamycin. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
NF-κB pathway inhibitor. Any potential interaction or modulation of SPIN3 by the NF-κB pathway can be influenced by BAY 11-7082. | ||||||
ZM 336372 | 208260-29-1 | sc-202857 | 1 mg | $46.00 | 2 | |
Raf-1 kinase inhibitor. If SPIN3 is linked to the Raf/MEK/ERK signaling, ZM 336372 can alter its activity. | ||||||
Calphostin C | 121263-19-2 | sc-3545 sc-3545A | 100 µg 1 mg | $336.00 $1642.00 | 20 | |
PKC inhibitor. Any potential influence of PKC-mediated pathways on SPIN3 can be affected by Calphostin C. | ||||||