Calphostin C CAS: 121263-19-2
MF: C44H38O14
MW: 790.80
An inhibitor of PKC, PKA, PKG, and calcium channel proteins.

Calphostin C (CAS 121263-19-2)

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Applicazione: Calphostin C is an inhibitor of PKC, PKA, PKG, and calcium channel proteins
Numero CAS: 121263-19-2
Purezza: ≥95%
Peso molecolare: 790.80
Formula molecolare: C44H38O14
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

Calphostin C is a novel, cell permeable, potent and highly selective inhibitor of protein kinase C (IC50=0.05 µM). Calphostin C has been shown to compete at the DAG binding site and inhibit DGK (DAG kinase, DAGK). Calphostin inhibition of PKC is light dependent. At higher concentrations it inhibits myosin light chain kinase, PKA (cAMP-dependent protein kinase), protein kinase G, c-Src (pp60v-src protein TyK) (tyrosine kinase) and DGK. This compound also inhibits PC-PLD1 and -PLD2 (Phospholipase D1 and D2, PLD1 and PLD2). Calphostin C has been observed to induce apoptotic DNA fragmentation and cell death. This compound has demonstrated the ability to inhibit cardiac L-type Ca2+ channels. It has demonstrated the ability to Inhibit cardiac L-type calcium channel protein inhibitors. Calphostin C is an inhibitor of MYLK, PKA and PKD.


Referenze

1. Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159: 548-553. PMID: 2467670
2. Kobayashi, E., et al. 1989. J. Antibiot. 42: 1470-1474. PMID: 2478514
3. Iida, T., et al. 1989. J. Antibiot. 42: 1475-1481. PMID: 2478515
4. Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176: 288-293. PMID: 1708246
5. Sciorra, V.A., et al. 2001. Biochemistry. 40: 2640-2646. PMID: 11327888

Stato fisico :
Solid
Solubilità :
Soluble in ethanol (1 mg/ml), DMSO (1 mg/ml), and DMF (1 mg/ml). Insoluble in water.
CONSERVAZIONE :
Store at -20° C
Punto di ebollizione :
1037.77° C at 760 mmHg (Predicted)
Densità :
~1.5 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.71 (Predicted)
IC50 :
protein kinase C: IC50 = 50 nM; myosin light chain kinase : IC50 = >5 µM; protein kinase A: IC50 = > 50 µM; protein kinase G: IC50 = > 25 µM; p60v-src: IC50 = > 50 µM
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
FF7380000
PubChem CID :
Numero MDL :
MFCD00133155
SMILES :
CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7

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Calphostin C (CAS 121263-19-2)  Citazioni prodotti

Vedi quanti altri hanno usato Calphostin C (CAS 121263-19-2). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 18 totali

PMID: # 29030553  Zhu, M. et al. 2017. Nat Commun. 8: 921.

PMID: # 26608789  2016. Am. J. Physiol. Renal Physiol. 310: F284-93.

PMID: # 26689644  Ojani, R. et al. 2016. Insect Biochem. Mol. Biol. 70: 44-52.

PMID: # 27353086  Lange, S.|Gehmlich, K.|Lun, AS.|Blondelle, J.|Hooper, C.|Dalton, ND.|Alvarez, EA.|Zhang, X.|Bang, ML.|Abassi, YA.|Dos Remedios, CG.|Peterson, KL.|Chen, J.|Ehler, E.| et al. 2016. Nat Commun. 7: 12120.

PMID: # 25985283  Catrow, JL. et al. 2015. J. Med. Chem. 58: 4678-92.

PMID: # 26277392  Ishima, Y. et al. 2015. Biochem. Biophys. Res. Commun. 465: 481-7.

PMID: # 23562553  Lee, SH. et al. 2013. Biochim. Biophys. Acta. 1830: 4017-29.

PMID: # 14976190  Catley, M.C. et al. 2004. J. Biol. Chem. 279: 18457-18466.

PMID: # 12600916  Cosentino, F. et al. 2003. Circulation. 107: 1017-1023.

PMID: # 11884456  Juang, Y.T. et al. 2002. J. Immunology. 168: 2865-2871.

Ciatazioni 1 a10 di 18 totali
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