SPERT Inhibitors
SPERT inhibitors are a class of chemical compounds that specifically target and inhibit the activity of SPERT (Sperm Associated Antigen 2), a protein involved in the organization of microtubules and intracellular transport. SPERT is known to play a role in regulating cytoskeletal structures, particularly microtubules, which are essential for cellular processes such as cell division, motility, and intracellular trafficking. By interacting with microtubule-associated proteins, SPERT helps maintain the integrity and function of these structures. Inhibition of SPERT disrupts these processes, leading to altered microtubule dynamics and changes in cellular architecture, which is important for understanding how cells regulate their shape, division, and transport mechanisms.
SPERT inhibitors provide valuable insights into the molecular mechanisms governing cytoskeletal dynamics. By blocking the activity of SPERT, researchers can study how the protein interacts with other cellular components, such as centrosomes and spindle fibers, during key processes like mitosis and intracellular movement. Inhibiting SPERT reveals the specific roles it plays in stabilizing microtubules and regulating their assembly and disassembly. This contributes to a broader understanding of the complex interplay between cytoskeletal proteins and cellular functions. The use of SPERT inhibitors in research helps to map out the pathways that control cellular organization and responses to structural demands, deepening our knowledge of cell biology and cytoskeletal regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A inhibits histone deacetylases, which could lead to hyperacetylation of histones, potentially repressing the transcription of "Cby2" by altering chromatin structure and making the gene less accessible for transcription factors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor, which may cause hypermethylation of the "Cby2" gene promoter, leading to decreased expression of "chibby family member 2" by silencing gene transcription. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, an HDAC inhibitor, potentially changes the chromatin structure around the "Cby2" gene, decreasing the expression of "chibby family member 2" by affecting transcriptional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as an HDAC inhibitor, possibly reducing "Cby2" gene expression by causing an accumulation of acetylated histones, leading to a more closed chromatin conformation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to GC-rich DNA sequences, potentially blocking transcription factor access to the "Cby2" gene promoter, resulting in decreased expression of "chibby family member 2." | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can alkalinize lysosomes and inhibit autophagy, which might lead to an accumulation of cellular stressors that downregulate "Cby2" expression indirectly. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is known to inhibit transcription broadly and could suppress the expression of "Cby2" by preventing RNA polymerase II activity on the gene. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which may lead to a reduction in protein synthesis including that of "chibby family member 2" by altering the translation machinery's activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA at transcription initiation complexes, potentially inhibiting transcription of "Cby2" and lowering the levels of "chibby family member 2." | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib, a proteasome inhibitor, might indirectly decrease the expression of "Cby2" by causing an accumulation of misfolded proteins, leading to cellular stress responses. | ||||||