SPEM1 Inhibitors
SPEM1 inhibitors LY294002 and Rapamycin target the PI3K/AKT/mTOR signaling axis, a pathway integral to cell growth, proliferation, and survival. Inhibition of this pathway by these chemicals may result in reduced activity of proteins regulated by this signaling cascade, including the SPEM1. Other inhibitors, such as PD98059, SB203580, and SP600125, target the MAPK signaling pathways. These pathways are pivotal in the control of cellular responses to growth signals, stress, and inflammatory cytokines. Inhibition of these kinases can lead to alterations in gene expression, cell differentiation, or apoptosis, affecting the functional state of proteins like SPEM1 that may be downstream effectors.
Compounds like BAPTA-AM and Thapsigargin can alter intracellular calcium levels, a signaling ion that modulates numerous cellular functions, including enzyme activity, gene transcription, and muscle contraction. If SPEM1 is sensitive to calcium levels, these agents can modulate its activity by altering the calcium signaling within the cell. Kinase inhibitors such as Go6983 and Y-27632 are known to impact a variety of signaling pathways by inhibiting protein kinases involved in cell proliferation, apoptosis, and cytoskeletal organization. Through their broad-spectrum activity, these inhibitors can affect the signaling pathways that SPEM1 is part of, leading to changes in its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
A potent inhibitor of PI3K, LY294002 can reduce phosphorylation events downstream of PI3K, potentially affecting SPEM1 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Known to inhibit mTOR, Rapamycin can alter protein synthesis and cell growth pathways that may be linked to SPEM1 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
By inhibiting MEK1/2, PD98059 can prevent the activation of the ERK pathway, potentially influencing SPEM1-related processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
An inhibitor of p38 MAPK, SB203580 can alter stress-responsive signaling pathways that SPEM1 may be a part of. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
This compound inhibits JNK, which could affect apoptosis and other cellular processes involving SPEM1. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $199.00 $460.00 $1479.00 | 1 | |
As a potent P2X1 receptor antagonist, NF449 can influence purinergic signaling, potentially impacting SPEM1 activity. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
A calcium chelator that can reduce intracellular calcium levels, possibly affecting calcium-dependent SPEM1 activity. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
A broad-spectrum protein kinase C inhibitor, Go6983 can impact signaling pathways where SPEM1 may play a role. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
A ROCK inhibitor, Y-27632 can prevent actin cytoskeleton reorganization, potentially influencing SPEM1 if it is associated with it. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
This Aurora kinase inhibitor can affect cell cycle progression, which may indirectly inhibit SPEM1 if it is cell cycle-dependent. | ||||||