Speedy E3 Inhibitors
Speedy E3 inhibitors represent a group of chemical substances that focus on modulating the activity of specific enzymes known as E3 ubiquitin ligases. These ligases are pivotal components of the ubiquitin-proteasome system, a crucial cellular pathway responsible for the degradation of proteins. They act by tagging proteins with a small protein called ubiquitin, a signal that marks them for degradation by the proteasome, which is effectively the cell's recycling center. This tagging process is highly selective and regulated, ensuring that proteins are degraded at appropriate times. E3 ubiquitin ligases are the substrate recognition modules of this system and, therefore, determine the specificity of protein degradation. Speedy E3 inhibitors, by their action, aim to intercept this process, leading to an accumulation of substrates that are normally marked for degradation.
The ubiquitin-proteasome system plays a central role in a myriad of cellular processes, including cell cycle regulation, signal transduction, and responses to oxidative stress, among others. The precise inhibition of E3 ubiquitin ligases by Speedy E3 inhibitors allows for the modulation of this system, which can affect various cellular pathways. By preventing the ubiquitination of certain proteins, Speedy E3 inhibitors can influence the stability and activity of those proteins, potentially leading to an array of cellular outcomes. The design of these inhibitors is based on an intricate understanding of the structure and function of E3 ligases, and the development of molecules that can selectively bind to these enzymes with high affinity. Such inhibitors often mimic or compete with the natural substrates of the ligases or interfere with the E2-E3 ligase interaction necessary for ubiquitin transfer.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a selective inhibitor of cyclin-dependent kinases (CDKs). By inhibiting CDK2, it can prevent the phosphorylation of Speedy E3, which is necessary for its activation in cell cycle progression. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Olomoucine is another CDK inhibitor, similar to Roscovitine, with a preference for CDK1, CDK2, and CDK5. Inhibition of these kinases can reduce the activity of Speedy E3 by hindering necessary phosphorylation events. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Purvalanol A is a potent and selective inhibitor of CDKs, particularly CDK1 and CDK2. By inhibiting these kinases, it can lead to the inactivation of Speedy E3 due to the lack of activating phosphorylations. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol inhibits multiple CDKs and can cause a broad interruption of cell cycle-related kinases, indirectly preventing Speedy E3 from being properly activated due to the suppression of CDK-mediated phosphorylation. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $79.00 $321.00 $671.00 | 1 | |
This compound is a CDK inhibitor that can block the cell cycle at the G1/S and G2/M transitions, potentially interfering with Speedy E3 activation by inhibiting the kinases that phosphorylate it. | ||||||
AT7519 | 844442-38-2 | sc-364416 sc-364416A sc-364416B sc-364416C | 5 mg 10 mg 100 mg 1 g | $291.00 $341.00 $1046.00 $3126.00 | 1 | |
AT7519 is a multi-CDK inhibitor that can block the progression of the cell cycle, indirectly reducing the functional activity of Speedy E3 through inhibition of kinase activity necessary for Speedy E3's function. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
Dinaciclib is a potent CDK inhibitor with broad activity. It can inhibit the phosphorylation of proteins involved in cell cycle regulation, thereby potentially causing a decrease in Speedy E3 activity. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Also known as Palbociclib, this selective inhibitor of CDK4 and CDK6 can indirectly affect Speedy E3 function by altering downstream cell cycle events that Speedy E3 is involved in. | ||||||
SNS-032 | 345627-80-7 | sc-364621 sc-364621A | 5 mg 10 mg | $169.00 $262.00 | ||
SNS-032 is a selective inhibitor of CDK2, CDK7, and CDK9, which can lead to decreased Speedy E3 activity by preventing phosphorylation events that are crucial for its activity. | ||||||
N-[5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinyl]-5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyrimidinamine Methanesulfonate | 1231930-82-7 | sc-496536 | 2.5 mg | $398.00 | ||
Also known as Abemaciclib, this inhibitor of CDK4 and CDK6 can indirectly lead to reduced Speedy E3 activity by changing the dynamics of cell cycle progression in which Speedy E3 participates. | ||||||