spectrin β IV Inhibitors
Spectrin β IV (SPTBN4) inhibitors encompass a variety of chemicals that indirectly modulate the function and activity of SPTBN4, a protein integral to the structural integrity and function of neurons. These inhibitors do not directly target SPTBN4 but influence related cellular processes and structures, such as cytoskeletal dynamics and neuronal signaling. For instance, compounds like Paclitaxel, Colchicine, Vinblastine, and Nocodazole affect microtubule stability and organization, indirectly impacting the role of SPTBN4 in maintaining neuronal structure. Similarly, agents that modulate actin dynamics, like Phalloidin and Cytochalasin D, can influence the interaction of SPTBN4 with the actin cytoskeleton, affecting its function in neurons.
Other inhibitors, such as Blebbistatin and Y-27632, which target myosin II activity and ROCK signaling respectively, can indirectly affect SPTBN4 by altering cytoskeletal tension and dynamics. Lithium and Forskolin, known for their roles in modulating neuronal signaling, represent another approach to influencing SPTBN4's function by affecting signaling pathways within neurons. Tetrodotoxin, a sodium channel blocker, and BAPTA-AM, a calcium chelator, can also indirectly impact SPTBN4 by modulating neuronal activity and intracellular calcium levels, respectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules, potentially affecting cytoskeletal dynamics and indirectly influencing SPTBN4's role in neurons. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Disrupts microtubule polymerization, can affect cytoskeletal organization, potentially impacting SPTBN4 function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Inhibits microtubule assembly, can indirectly affect SPTBN4's role in maintaining neuronal structure. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Microtubule depolymerizing agent, can influence cytoskeletal dynamics, indirectly impacting SPTBN4 activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Modulates neuronal signaling, can indirectly influence SPTBN4's role in neurons. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes actin filaments, can affect actin dynamics, indirectly impacting SPTBN4's interaction with the cytoskeleton. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Disrupts actin polymerization, potentially affecting SPTBN4's role in cytoskeletal organization. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II, can indirectly affect SPTBN4 by altering cytoskeletal tension and dynamics. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Activates adenylate cyclase, can modulate neuronal signaling, indirectly affecting SPTBN4. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
Calcium chelator, can affect intracellular calcium levels, potentially influencing SPTBN4's role in neuronal signaling. | ||||||