SPDL-1 Activators
SPDL-1 activators encompass a range of chemical entities that may influence the activity or function of SPDL1 indirectly. This is largely through their impact on cellular processes or pathways related to spindle dynamics or cell cycle progression, both of which are domains where SPDL1 exerts its effects. Chemicals such as Nocodazole and Paclitaxel modulate microtubule dynamics by either destabilizing or stabilizing them, respectively. Such modulation can inherently affect proteins like SPDL1 that are integral to proper spindle assembly and function. Similarly, the inclusion of agents like BI 2536 or Hesperadin, which target kinases like Plk1 or Aurora kinases, underscores the interconnected nature of spindle regulatory pathways. These kinases, with their roles in spindle assembly and checkpoint control, represent critical nodes that can indirectly shape SPDL1's activity. Additionally, chemicals like MG132, by inhibiting proteasomes, could disrupt the turnover of spindle-associated proteins, potentially influencing SPDL1 indirectly. The overarching theme among these activators is their involvement in or effect on mitotic spindle regulation, emphasizing the intricate network of pathways and processes that SPDL1 navigates within the cell.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Disrupts microtubule polymerization, which may indirectly affect SPDL1 as it plays a role in spindle dynamics. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Stabilizes microtubules and can affect spindle assembly, potentially influencing SPDL1's activity. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
Inhibits polo-like kinase (Plk1), a kinase involved in spindle regulation, which may indirectly influence SPDL1. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
A specific inhibitor of Eg5, a motor protein important for spindle formation, potentially affecting SPDL1. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
Inhibits Eg5 function, potentially affecting spindle dynamics and thus, SPDL1. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
Inhibits cyclin-dependent kinases involved in cell cycle progression, potentially influencing SPDL1. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A CDK inhibitor that can affect cell cycle progression and thus, potentially SPDL1's function in spindle dynamics. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
Inhibits Aurora kinase, another key player in spindle dynamics, which may indirectly influence SPDL1. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor which can affect protein turnover and spindle associated proteins, potentially affecting SPDL1. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Inhibits Aurora B kinase and can affect spindle checkpoint, potentially influencing SPDL1's activity. | ||||||