SPAG16 Inhibitors
SPAG16 inhibitors target the protein SPAG16 (Sperm Associated Antigen 16). This protein, like SPAG1, is associated with the sperm tail and is vital for spermatogenesis, particularly in the regulation of sperm motility. SPAG16 is a part of the central apparatus of the axoneme, a cellular structure found in flagella and cilia. The axoneme's proper function ensures the movement capability of these cellular extensions. In the context of sperm cells, the axoneme ensures the necessary motility for the sperm to travel and achieve fertilization. Mutations or dysfunctions in SPAG16 can lead to compromised sperm motility and subsequently affect male fertility.
Chemical inhibitors of SPAG16 act by interfering with the expression, function, or activity of the SPAG16 protein. The precise mechanisms of action of these inhibitors can vary, but they generally work at the molecular level to disrupt the protein's normal function. Some inhibitors might prevent the synthesis of the protein, while others might hinder its interaction with other proteins or cellular components. Given the protein's role in sperm motility, SPAG16 inhibitors can have a profound impact on sperm function. While the protein's primary association is with male reproduction, the broader role of cilia and flagella in various cellular functions means that the effects of SPAG16 inhibition might extend beyond the reproductive system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine disrupts microtubule polymerization, which is essential for sperm flagella formation that SPAG16 is involved in. By destabilizing microtubules, colchicine functionally inhibits SPAG16's role in the structural integrity of the sperm tail. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that can inhibit SPAG16 by disrupting the microtubule dynamics crucial for its function in the axoneme of cilia and flagella. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and in doing so can prevent the proper function of SPAG16 which requires dynamic microtubules for cilia and flagella structure and motility. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation, which can inhibit SPAG16's role in sperm tail structure and function by preventing proper axonemal assembly. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, potentially inhibiting the function of SPAG16 in maintaining axonemal microtubules and thus affecting sperm motility. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization. Since SPAG16 is associated with the axonemal microtubules, this inhibition can directly affect SPAG16's role in ciliary and flagellar motion. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, which could inhibit the proper functioning of SPAG16 associated with the axonemal structure of flagella and cilia. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin binds to tubulin at the colchicine site and inhibits its polymerization, which would inhibit SPAG16's function in the structural maintenance of cilia and flagella. | ||||||
Noscapine | 128-62-1 | sc-219418 | 10 mg | $102.00 | ||
Noscapine binds to tubulin and alters its conformation, which could inhibit SPAG16 by disrupting the microtubule dynamics required for its role in flagella and cilia. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits microtubule polymerization, which could functionally inhibit SPAG16 by affecting its role in the formation and maintenance of the axoneme in flagella. | ||||||