SP140L Activators
Chemicals that can function as SP140L activators are mainly involved in altering the chromatin landscape or influencing signaling pathways that intersect with chromatin remodeling activities. For instance, Anacardic Acid and CTPB are activators of histone acetyltransferase p300, a pivotal component in chromatin modification. By increasing histone acetylation, these activators create a more open chromatin structure, facilitating SP140L's role in gene expression. Similarly, activators like Forskolin and IBMX, which elevate cAMP levels, can potentially impact PKA-dependent signaling pathways. These pathways might intersect with chromatin remodeling activities, thus indirectly supporting SP140L functions.
Another category of chemicals, such as I-BET151 and PGE2, exert their effects by modulating specific proteins that interact with chromatin. I-BET151 selectively activates BRD4, a protein associated with chromatin remodeling, while PGE2 impacts EPAC, a downstream effector in cAMP signaling. By targeting these proteins, these activators can influence the specific biochemical context within which SP140L operates, thereby contributing to its activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $100.00 $200.00 | 13 | |
Activates p300, a histone acetyltransferase (HAT), leading to increased histone acetylation which can make chromatin accessible for SP140L. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increases cAMP, which can affect PKA-dependent signaling possibly enhancing SP140L interaction with chromatin. | ||||||
I-BET 151 Hydrochloride | 1300031-49-5 (non HCl Salt) | sc-391115 | 10 mg | $450.00 | 2 | |
Selectively activates BRD4, which in turn might alter chromatin to facilitate SP140L activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Activates EPAC, a downstream effector in cAMP signaling; could indirectly facilitate SP140L interactions with chromatin. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
PDE inhibitor, raises cAMP levels and could potentially enable SP140L activation via PKA-dependent pathways. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Promotes histone acetylation, creating a chromatin landscape that may allow SP140L to function more effectively. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
cAMP analog, activates PKA which could then potentially influence SP140L-related pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
PDE inhibitor, raises cAMP and cGMP levels, which may indirectly allow for SP140L activation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
Cell-permeable cAMP analog that can activate PKA and may influence pathways that SP140L is involved in. | ||||||
8-Bromo-cGMP | 51116-01-9 | sc-200316 sc-200316A | 10 mg 50 mg | $102.00 $347.00 | 7 | |
cGMP analog that can activate PKG and might indirectly affect SP140L activation in related pathways. | ||||||