SOCS-1 Activators
SOCS-1, a sentinel in cellular regulation, orchestrates a crucial role in fine-tuning immune responses and maintaining cellular homeostasis. As an integral component of the JAK/STAT signaling pathway, its primary function lies in dampening cytokine-induced signaling cascades, hindering excessive cellular responses. Upon activation, SOCS-1 exerts its inhibitory effect by interacting with JAKs and cytokine receptors, hindering further signal transduction. This interaction impedes the phosphorylation of downstream targets, particularly STAT proteins, thus regulating gene expression and cellular responses.
Beyond its role as a JAK/STAT pathway regulator, SOCS-1 also intricately interacts with other signaling pathways. Its modulation by activators such as Bay 11-7082, and EGCG highlights the interconnectedness of SOCS-1 with NF-κB, MAPK, and PI3K/Akt pathways. These interactions contribute to a delicate cellular balance, ensuring proper immune responses and stopping aberrant cell behavior. In summary, SOCS-1 serves as a molecular checkpoint, finely adjusting cellular responses to maintain immune balance and prevents inflammatory overdrive. The elucidation of SOCS-1 activators provides a nuanced understanding of the molecular intricacies underlying immune regulation, opening avenues for targeted interventions in cellular signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibitor of NF-κB activation. Reduces SOCS-1 degradation by inhibiting the proteasomal pathway. This action indirectly activates SOCS-1, enhancing its inhibitory effect on JAK/STAT signaling and promoting immune response regulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Main catechin in green tea. Modulates MAPK and PI3K/Akt pathways, indirectly influencing SOCS-1. Enhances SOCS-1-mediated inhibition of JAK/STAT signaling by stabilizing the protein. This indirect modulation contributes to the activation of SOCS-1. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Triterpenoid with anti-inflammatory properties. Targets the NF-κB pathway, indirectly influencing SOCS-1. Suppresses NF-κB, enhancing SOCS-1 stability and function. This indirect modulation contributes to the activation of SOCS-1 and regulation of JAK/STAT signaling. | ||||||
Gingerol | 23513-14-6 | sc-201519 sc-201519A | 5 mg 20 mg | $109.00 $387.00 | 5 | |
Active compound in ginger. Modulates the PI3K/Akt pathway, indirectly impacting SOCS-1. Influences Akt, enhancing SOCS-1 stability and function. This indirect modulation contributes to the activation of SOCS-1 and regulation of JAK/STAT signaling. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Gold-containing compound with anti-inflammatory effects. Targets the NF-κB pathway, indirectly influencing SOCS-1. Inhibits NF-κB, enhancing SOCS-1 stability and function. This indirect modulation contributes to the activation of SOCS-1 and regulation of JAK/STAT signaling. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Pentacyclic triterpenoid with anti-inflammatory properties. Targets the NF-κB pathway, indirectly influencing SOCS-1. Inhibits NF-κB, enhancing SOCS-1 stability and function. This indirect modulation contributes to the activation of SOCS-1 and regulation of JAK/STAT signaling. | ||||||
Baicalein | 491-67-8 | sc-200494 sc-200494A sc-200494B sc-200494C | 10 mg 100 mg 500 mg 1 g | $32.00 $42.00 $162.00 $292.00 | 12 | |
Flavonoid compound with anti-inflammatory effects. Targets the PI3K/Akt pathway, indirectly influencing SOCS-1. Modulates Akt, enhancing SOCS-1 stability and function. This indirect modulation contributes to the activation of SOCS-1 and regulation of JAK/STAT signaling. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
JAK1/2 inhibitor that indirectly activates SOCS-1. Blocks JAK1/2 activity, preventing phosphorylation of SOCS-1, leading to increased stability and function. This indirect activation enhances SOCS-1-mediated inhibition of JAK/STAT signaling and modulates cellular responses. | ||||||