Snf1 Activators
Chemicals classified as Snf1 activators primarily function by modulating energy metabolism pathways, leading to an increase in the AMP/ATP ratio, which in turn activates Snf1. Activators of this class inhibit the mitochondrial respiratory chain complex 1 or glycolysis respectively, causing an energy stress condition that activates Snf1. These molecules, by causing an increase in the AMP/ATP ratio, induce a state of energy stress in the cell, leading to the activation of Snf1.
Snf1 activators function by activating AMPK, the mammalian homologue of Snf1. These compounds activate AMPK, which shares a similar energy sensing role with Snf1, suggesting that they can also activate Snf1 in yeast. These molecules, by specifically activating AMPK, may indirectly lead to the activation of Snf1, highlighting the conserved role of these kinases in maintaining energy homeostasis in cells.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin indirectly activates Snf1 by inhibiting mitochondrial respiratory chain complex 1, leading to an increase in the AMP/ATP ratio, which in turn activates Snf1. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is converted into ZMP in cells, which mimics AMP and activates AMPK, the mammalian homologue of Snf1. This can lead to the activation of Snf1 in yeast. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis, causing an increase in the AMP/ATP ratio, which can activate Snf1. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin, like metformin, inhibits mitochondrial respiratory chain complex 1, leading to an increase in the AMP/ATP ratio, which can activate Snf1. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is reported to activate AMPK, the mammalian homologue of Snf1, potentially leading to the activation of Snf1 in yeast. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can activate AMPK, the mammalian homologue of Snf1, potentially leading to the activation of Snf1 in yeast. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is reported to activate AMPK, the mammalian homologue of Snf1, potentially leading to the activation of Snf1 in yeast. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $47.00 $94.00 $119.00 | 3 | |
Salicylate can activate AMPK, the mammalian homologue of Snf1, potentially leading to the activation of Snf1 in yeast. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone can activate AMPK, the mammalian homologue of Snf1, potentially leading to the activation of Snf1 in yeast. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate can activate AMPK, the mammalian homologue of Snf1, potentially leading to the activation of Snf1 in yeast. | ||||||