SMUG1 Inhibitors
SMUG1 inhibitors belong to a specific class of chemical compounds that are primarily designed to target and modulate the activity of the SMUG1 enzyme. SMUG1, which stands for Single-Strand Selective Monofunctional Uracil-DNA Glycosylase 1, is an essential enzyme involved in the base excision repair (BER) pathway, a critical mechanism responsible for maintaining genomic stability. SMUG1 is particularly known for its role in recognizing and excising uracil bases from DNA molecules. This process is crucial in repairing DNA damage caused by the spontaneous deamination of cytosine to uracil, as well as other forms of DNA lesions resulting from various endogenous and exogenous factors.
SMUG1 inhibitors are designed to interfere with the normal enzymatic activity of SMUG1, thereby modulating its role in the BER pathway. These inhibitors typically work by binding to the active site of SMUG1, it from efficiently recognizing and removing uracil bases from DNA. As a consequence, the repair of DNA lesions becomes compromised, potentially leading to the accumulation of DNA damage and genomic instability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine is an isoquinoline alkaloid that can inhibit SMUG1 by intercalating into DNA and affecting its structure, which may impede the access of SMUG1 to its substrate. | ||||||
6-Thioguanine | 154-42-7 | sc-205587 sc-205587A | 250 mg 500 mg | $42.00 $54.00 | 3 | |
Thioguanine is a guanine analog that gets incorporated into DNA and can alter DNA structure, which may decrease the efficiency of SMUG1-mediated repair processes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a polyphenol from green tea, has been shown to inhibit various DNA repair enzymes; it may bind to DNA and affect SMUG1's interaction with DNA. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid, a polyphenol, can bind to DNA and potentially inhibit DNA repair enzymes like SMUG1 by steric hindrance. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a tetracyclic diterpene that inhibits DNA polymerases and can indirectly inhibit SMUG1 by disrupting the DNA replication process where SMUG1 is involved. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $112.00 $459.00 | 8 | |
Beta-Lapachone, a natural naphthoquinone compound, can lead to an increase in reactive oxygen species, possibly causing oxidative DNA damage that may overwhelm SMUG1 repair capacity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide, a topoisomerase II inhibitor, causes DNA breaks and can lead to an accumulation of DNA damage, which may saturate SMUG1's repair activity. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is an alkylating agent that can form DNA cross-links, potentially limiting the access of SMUG1 to DNA and inhibiting its function. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid, a pentacyclic triterpenoid, can modulate oxidative stress and DNA damage responses, which may affect the activity of SMUG1 indirectly. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is an antimalarial drug that also intercalates into DNA, which could interfere with SMUG1's ability to access its substrate. | ||||||