Smo Inhibitors
Items 1 to 10 of 13 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vismodegib | 879085-55-9 | sc-396759 sc-396759A | 10 mg 25 mg | $82.00 $158.00 | 1 | |
Binds to SMO and inhibits the Hedgehog signaling pathway, preventing the activation of downstream transcription factors and target genes. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
A natural compound that disrupts SMO function by binding to its extracellular domain, inhibiting Hedgehog signaling pathway activation. | ||||||
Jervine | 469-59-0 | sc-200934 sc-200934A | 1 mg 5 mg | $66.00 $240.00 | 1 | |
Jervine may target the extracellular or transmembrane domains of Smo, preventing its activation and downstream signaling. This inhibition disrupts the Hedgehog pathway, impacting processes like cell growth, differentiation, and tissue patterning. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
SANT-1 acts as a Smo modulator by selectively disrupting the interaction between Smo and its downstream signaling partners. Its unique hydrophobic regions facilitate specific binding, enhancing the stability of the Smo protein's inactive state. The compound's kinetic profile reveals a rapid association and slower dissociation, allowing for prolonged modulation of signaling pathways. Furthermore, SANT-1's ability to form transient complexes with key residues alters conformational dynamics, impacting cellular signaling cascades. | ||||||
SANT-2 | 329196-48-7 | sc-202801 | 1 mg | $140.00 | ||
SANT-2 functions as a Smo modulator by engaging in distinct molecular interactions that stabilize the inactive conformation of the Smo protein. Its unique structural features promote selective binding to critical allosteric sites, effectively hindering the activation of downstream signaling pathways. The compound exhibits a unique reaction kinetics profile, characterized by a moderate association rate and a gradual dissociation, which prolongs its modulatory effects. Additionally, SANT-2's capacity to induce conformational changes in Smo enhances its regulatory potential, influencing cellular responses. | ||||||
MRT 10 | 330829-30-6 | sc-364543 sc-364543A | 5 mg 50 mg | $159.00 $645.00 | ||
MRT 10 acts as a Smo modulator through its ability to disrupt the typical conformational dynamics of the Smo protein. It selectively targets specific hydrophobic pockets, leading to a unique stabilization of the inactive state. The compound's interaction profile is marked by rapid binding kinetics, allowing for swift modulation of Smo activity. Furthermore, MRT 10's distinct steric properties facilitate unique intermolecular interactions, enhancing its regulatory influence on signaling cascades. | ||||||
Glasdegib | 1095173-27-5 | sc-507353 | 5 mg | $165.00 | ||
A SMO inhibitor that suppresses the Hedgehog pathway by binding to SMO, leading to downregulation of downstream target gene transcription. | ||||||
Erismodegib | 956697-53-3 | sc-396280 sc-396280A | 10 mg 100 mg | $255.00 $918.00 | ||
Inhibits SMO, interfering with Hedgehog pathway activation and modulating the expression of genes involved in cell proliferation. | ||||||
Itraconazole | 84625-61-6 | sc-205724 sc-205724A | 50 mg 100 mg | $78.00 $142.00 | 23 | |
Researched for its antifungal properites,Itraconazole may inhibit Hedgehog signaling by targeting SMO, disrupting the pathway and gene expression. | ||||||
PF-5274857 | 1373615-35-0 | sc-478208 | 5 mg | $360.00 | ||
Binds to SMO and inhibits Hedgehog signaling, potentially affecting gene expression and cell proliferation in Hedgehog-dependent cells. | ||||||