Date published: 2026-5-16

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SMF_Hmgxb3 Inhibitors

SMF_Hmgxb3 inhibitors constitute a specialized class of chemical compounds designed to selectively modulate the activity of the SMF (Structural Maintenance of Chromosomes) domain-containing protein HMGXB3. The HMGXB3 protein is characterized by the presence of a high mobility group box (HMG-box) domain, indicative of its involvement in DNA binding and chromosomal maintenance. The inhibitors developed for SMF_Hmgxb3 exhibit a specific chemical structure, allowing them to interact selectively with defined binding sites on the HMGXB3 protein, thereby influencing its molecular activities within the cellular context. The meticulous design of these inhibitors is essential for ensuring a high degree of specificity, minimizing unintended effects on other cellular components or proteins within the broader SMF domain-containing family.

The mechanism of action of SMF_Hmgxb3 inhibitors involves disrupting the normal functioning of the HMGXB3 protein, potentially impacting processes associated with chromosomal maintenance and DNA organization. As a member of the SMF domain-containing family, HMGXB3 may play a role in regulating the structural integrity of chromosomes during various cellular processes, including cell division and DNA repair. The selectivity of these inhibitors is crucial to prevent interference with other closely related SMF domain-containing proteins or chromosomal maintenance pathways. As researchers delve into the intricacies of genomic stability and chromosomal dynamics, SMF_Hmgxb3 inhibitors serve as valuable tools, allowing for the investigation of the precise molecular mechanisms governed by HMGXB3. The study of this chemical class contributes to a deeper understanding of the role played by SMF_Hmgxb3 in cellular physiology, offering insights into its potential functions within the complex networks that regulate chromosomal architecture and genomic stability. Overall, the exploration of SMF_Hmgxb3 inhibitors provides a platform for advancing our understanding of the molecular landscape surrounding SMF domain-containing proteins and their roles in maintaining genomic integrity.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Sirolimus forms a complex with FKBP12 and inhibits mTOR, a kinase important for protein synthesis, which might reduce the expression of proteins like HMGXB3.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

Cycloheximide inhibits eukaryotic protein synthesis by interfering with the translocation step on ribosomes, potentially decreasing HMGXB3 protein levels.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$43.00
$189.00
$316.00
$663.00
6
(1)

DRB inhibits RNA synthesis by blocking the activation of RNA polymerase II, which could consequently reduce HMGXB3 expression.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$51.00
$231.00
$523.00
63
(1)

Etoposide inhibits DNA topoisomerase II, leading to DNA damage and possibly affecting transcription and expression of genes like HMGXB3.

Rocaglamide

84573-16-0sc-203241
sc-203241A
sc-203241B
sc-203241C
sc-203241D
100 µg
1 mg
5 mg
10 mg
25 mg
$275.00
$474.00
$1639.00
$2497.00
$5344.00
4
(1)

Rocaglamide has been reported to inhibit translation initiation and may reduce the synthesis of various proteins, including potentially HMGXB3.

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

Actinomycin D binds to DNA and inhibits RNA polymerase movement, thereby decreasing RNA synthesis and possibly affecting HMGXB3 expression.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

Triptolide has been shown to inhibit the transcription of various genes by affecting transcription factors and could potentially decrease HMGXB3 expression.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Chloroquine intercalates into DNA and RNA, which can disrupt replication and transcription processes, potentially affecting HMGXB3 expression.

Aphidicolin

38966-21-1sc-201535
sc-201535A
sc-201535B
1 mg
5 mg
25 mg
$84.00
$306.00
$1104.00
30
(3)

Aphidicolin is an inhibitor of DNA polymerase alpha and delta, leading to S-phase arrest in the cell cycle, which may reduce the expression of HMGXB3.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

Amanitin is an inhibitor of RNA polymerase II and III, preventing mRNA synthesis and potentially decreasing the expression of HMGXB3.