SMAP1L Inhibitors
Chemical inhibitors of SMAP1L can affect its function by targeting various cellular processes that are crucial for its role in membrane trafficking and cytoskeletal organization. Wortmannin, for example, inhibits phosphoinositide 3-kinases, which are upstream regulators of signaling pathways that SMAP1L relies on for proper functioning. This inhibition can impede the activation of downstream signals necessary for SMAP1L's involvement in membrane deformation and cytoskeletal reorganization. Similarly, PIK-93 targets phosphatidylinositol 4-kinase, disrupting lipid signaling that is vital for vesicle formation and trafficking, processes in which SMAP1L is actively involved. Cytochalasin D and Latrunculin A both disrupt actin polymerization; the former by capping filament ends and the latter by sequestering actin monomers. Since SMAP1L's function is related to the actin cytoskeleton, the prevention of actin fiber formation can inhibit the ability of SMAP1L to engage in membrane trafficking events.
On the other hand, ML141 inhibits the Cdc42 GTPase, a protein that regulates actin filament assembly and cellular morphology. By inhibiting Cdc42, ML141 can obstruct the cytoskeletal rearrangements necessary for SMAP1L's role in vesicle formation. Dynasore interrupts the function of dynamin, a GTPase essential for the scission of clathrin-coated vesicles during endocytosis, a pathway with which SMAP1L is associated. Jasplakinolide, in contrast, stabilizes actin filaments, preventing their disassembly, which can immobilize the dynamic structure of the actin cytoskeleton and thereby inhibit SMAP1L-dependent trafficking processes. Microtubule targeting compounds like Paclitaxel and Nocodazole also affect SMAP1L function but through different mechanisms; Paclitaxel stabilizes microtubules while Nocodazole causes their depolymerization, both of which can disrupt the microtubule dynamics that SMAP1L might coordinate with during membrane trafficking. Finally, Gö6976 inhibits protein kinase C isoforms that partake in signaling pathways influencing cytoskeletal organization, which in turn, can affect SMAP1L function related to membrane dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which indirectly leads to the inhibition of SMAP1L by preventing the activation of downstream signals that might be essential for SMAP1L function in membrane trafficking and cytoskeletal reorganization. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin polymerization, which is a crucial element of the cytoskeletal structure within cells. Since SMAP1L is associated with cytoskeletal dynamics through its function in membrane deformation and trafficking, the disruption of actin polymerization can inhibit the ability of SMAP1L to interact effectively with cellular membranes. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a small molecule that inhibits dynamin, a GTPase that SMAP1L may interact with during clathrin-mediated endocytosis. By inhibiting dynamin, Dynasore can inhibit the endocytic process, thereby hindering the role of SMAP1L in this pathway. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a potent and selective inhibitor of the Cdc42 GTPase. Since Cdc42 is involved in actin filament formation and cell shape changes, and SMAP1L is involved in membrane trafficking, the inhibition of Cdc42 can lead to the inhibition of SMAP1L activity by preventing proper cytoskeletal rearrangement and vesicle formation that is necessary for its function. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, destabilizing the actin cytoskeleton. As SMAP1L is important for membrane deformation and trafficking which relies on the integrity of the cytoskeleton, the inhibition of actin polymerization by Latrunculin A would lead to the inhibition of SMAP1L's function in these processes. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly. Since SMAP1L is functionally linked to membrane trafficking events that are often coordinated with microtubule dynamics, the stabilization of microtubules can inhibit the dynamic rearrangement necessary for SMAP1L to effectively aid in the trafficking processes. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that disrupts microtubule dynamics. Because SMAP1L is involved in membrane trafficking, which is often dependent on microtubule dynamics, the disruption caused by Nocodazole can inhibit the trafficking process and thus SMAP1L function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide is a cyclodepsipeptide that stabilizes actin filaments and prevents their depolymerization. By stabilizing actin filaments, Jasplakinolide can inhibit processes that require actin remodeling, which is essential for the function of SMAP1L in terms of membrane deformation and vesicle trafficking. | ||||||
NF449 | 627034-85-9 | sc-478179 sc-478179A sc-478179B | 10 mg 25 mg 100 mg | $203.00 $469.00 $1509.00 | 1 | |
NF449 is a potent and selective inhibitor of Gs-alpha subunit of G-proteins. By inhibiting Gs-alpha, NF449 can lead to reduced production of cyclic AMP (cAMP), which is a secondary messenger involved in a myriad of cellular processes, including those that may involve SMAP1L, thus inhibiting its function. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is an inhibitor of phosphatidylinositol 4-kinase (PI4K), which is involved in the generation of lipid signaling molecules. Since SMAP1L is involved in membrane trafficking, inhibition of PI4K by PIK-93 can lead to disruption of lipid signaling necessary for the formation of trafficking vesicles, thus inhibiting SMAP1L's role in vesicle-mediated transport. | ||||||