SLUG Activators
SLUG activators represent a specialized category of compounds designed to modulate the activity or expression of the SLUG protein, a transcription factor belonging to the Snail family of zinc finger proteins. SLUG, also known as Snail2, plays a pivotal role in gene regulation, particularly in processes such as embryonic development, stem cell maintenance, and epithelial-mesenchymal transition (EMT). As a transcriptional regulator, SLUG controls the expression of genes involved in cell adhesion, migration, and tissue remodeling. SLUG activators are meticulously crafted molecules engineered to enhance the activity or expression of SLUG, promoting its role in regulating gene expression patterns associated with cellular processes.
Chemically, SLUG activators are developed to modulate the activity of SLUG by either promoting its binding to specific DNA sequences or enhancing its expression levels. The molecular structure of these activators is intricately designed to interact with SLUG, aiming to augment its function without significantly affecting other cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A enhances SLUG activity by inhibiting histone deacetylases, promoting chromatin accessibility. This compound facilitates SLUG-mediated epithelial-mesenchymal transition, suggesting its involvement in modulating cellular plasticity and metastatic potential. | ||||||
Verteporfin | 129497-78-5 | sc-475698 sc-475698A | 10 mg 100 mg | $354.00 $2764.00 | 5 | |
Verteporfin enhances SLUG function by inhibiting YAP/TAZ activity, preventing SLUG degradation. This compound promotes SLUG-mediated epithelial-mesenchymal transition, indicating its role in modulating cellular plasticity and metastatic potential. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 enhances SLUG activity by inhibiting TGF-β receptor signaling, preventing SLUG degradation. This compound promotes SLUG-mediated epithelial-mesenchymal transition, indicating its involvement in modulating cellular plasticity and metastatic potential. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 enhances SLUG function by inhibiting BRD4, promoting chromatin accessibility. This compound facilitates SLUG-mediated epithelial-mesenchymal transition, suggesting its role in modulating cellular plasticity and metastatic potential. | ||||||
Chaetocin | 28097-03-2 | sc-200893 | 200 µg | $126.00 | 5 | |
Chaetocin enhances SLUG activity by inhibiting EZH2, promoting chromatin accessibility. This compound facilitates SLUG-mediated epithelial-mesenchymal transition, indicating its involvement in modulating cellular plasticity and metastatic potential. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
C646 enhances SLUG activity by inhibiting CBP/p300, promoting chromatin accessibility. This compound facilitates SLUG-mediated epithelial-mesenchymal transition, indicating its involvement in modulating cellular plasticity and metastatic potential. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 enhances SLUG function by inhibiting ROCK, preventing SLUG degradation. This compound promotes SLUG-mediated epithelial-mesenchymal transition, suggesting its role in modulating cellular plasticity and metastatic potential. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 enhances SLUG activity by inhibiting mTOR, promoting SLUG stability. This compound facilitates SLUG-mediated epithelial-mesenchymal transition, indicating its involvement in modulating cellular plasticity and metastatic potential. | ||||||
GSK-J4 | 1373423-53-0 | sc-507551 | 100 mg | $1275.00 | ||
GSK-J4 enhances SLUG function by inhibiting JMJD3, promoting chromatin accessibility. This compound facilitates SLUG-mediated epithelial-mesenchymal transition, suggesting its role in modulating cellular plasticity and metastatic potential. | ||||||