SLC39A12, or Solute Carrier Family 39 Member 12, is a protein encoded by the SLC39A12 gene in humans. This protein is part of the ZIP (Zrt-, Irt-like Protein) family, which plays a crucial role in the transport of zinc and other metal ions across cell membranes.Zinc is an essential trace element, vital for numerous biological processes, including enzyme function, protein synthesis, and cellular signaling. SLC39A12 functions as a zinc transporter, facilitating the uptake of zinc from the extracellular environment or intracellular stores into the cytoplasm. This regulation of zinc homeostasis is critical for maintaining cellular functions and overall health.
The exact physiological roles and mechanisms of SLC39A12 are still being researched. However, given the importance of zinc in numerous biological pathways, SLC39A12 likely plays a role in several key cellular processes, including immune function, neural development, and cellular metabolism.SLC39A12's role in zinc transport also implicates it in various health conditions. Imbalances in zinc levels, whether deficiency or excess, can lead to a range of health issues, including impaired immune response, neurological disorders, and developmental problems. Therefore, understanding the function and regulation of zinc transporters like SLC39A12 is crucial for comprehending these health issues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Increases available zinc ions, potentially enhancing SLC39A12-mediated zinc uptake. | ||||||
TPEN | 16858-02-9 | sc-200131 | 100 mg | $130.00 | 10 | |
A zinc chelator that can deplete zinc ions, indirectly affecting SLC39A12. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
Chelates zinc and other heavy metals, potentially influencing SLC39A12 activity. | ||||||
Deferoxamine | 70-51-9 | sc-507390 | 5 mg | $255.00 | ||
Primarily an iron chelator but also affects zinc homeostasis, potentially influencing SLC39A12. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that may modulate zinc transporter expression and activity, including SLC39A12. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol that can affect metal ion homeostasis, potentially impacting SLC39A12 activity. | ||||||
Clioquinol | 130-26-7 | sc-201066 sc-201066A | 1 g 5 g | $45.00 $115.00 | 2 | |
An antifungal agent that chelates zinc and copper, potentially influencing SLC39A12. | ||||||