SLC26A11 Inhibitors
SLC26A11 Inhibitors target various ion transporters and channels, influencing the functional context of SLC26A11. Given SLC26A11's role in chloride ion transport, modulation of related ion transport processes and cellular ion homeostasis could indirectly impact its activity. Diuretics like Furosemide and Hydrochlorothiazide, which affect sodium and chloride transport in the kidneys, could influence SLC26A11 by altering systemic chloride ion homeostasis. Anion transport inhibitors like DIDS and Niflumic Acid, known to target chloride channels, might also impact chloride transport mechanisms relevant to SLC26A11.
Compounds like CFTR Inhibitor-172, although specifically targeting the cystic fibrosis transmembrane conductance regulator, illustrate the interconnected nature of chloride transport systems, which could have implications for SLC26A11 function. Amiloride and Glyburide (Glibenclamide), affecting sodium and potassium channels, respectively, might also influence chloride balance and, in turn, SLC26A11 activity. Angiotensin II receptor blockers (ARBs) such as Valsartan and Losartan, and the carbonic anhydrase inhibitor Acetazolamide, affect electrolyte balance and transport, providing methods to study the role of SLC26A11 in chloride homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
Furosemide is a loop diuretic that inhibits the Na⁺/K⁺/2Cl⁻ cotransporter in the kidneys, potentially affecting chloride ion homeostasis and indirectly influencing SLC26A11. | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
Hydrochlorothiazide is a thiazide diuretic that inhibits the NaCl cotransporter, which might indirectly impact chloride transport and SLC26A11 function. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $31.00 | 3 | |
Niflumic Acid is a nonsteroidal anti-inflammatory drug (NSAID) known to inhibit chloride channels, potentially influencing SLC26A11 activity. | ||||||
CFTR Inhibitor-172 | 307510-92-5 | sc-204680 sc-204680A | 10 mg 50 mg | $165.00 $510.00 | 10 | |
CFTR Inhibitor-172 is specific for cystic fibrosis transmembrane conductance regulator, but its impact on chloride transport could indirectly affect SLC26A11. | ||||||
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a potassium-sparing diuretic that inhibits epithelial sodium channels, potentially impacting chloride homeostasis and SLC26A11 function. | ||||||
Glyburide (Glibenclamide) | 10238-21-8 | sc-200982 sc-200982A sc-200982D sc-200982B sc-200982C | 1 g 5 g 25 g 100 g 500 g | $45.00 $60.00 $115.00 $170.00 $520.00 | 36 | |
Glyburide (Glibenclamide) is a sulfonylurea drug that can inhibit ATP-sensitive potassium channels, potentially affecting chloride transport and SLC26A11. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $39.00 $90.00 $120.00 | 4 | |
Valsartan, an angiotensin II receptor blocker, can affect electrolyte balance and might indirectly influence SLC26A11. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan is another angiotensin II receptor blocker with potential indirect effects on electrolyte transport, including chloride ions, possibly affecting SLC26A11. | ||||||
Acetazolamide | 59-66-5 | sc-214461 sc-214461A sc-214461B sc-214461C sc-214461D sc-214461E sc-214461F | 10 g 25 g 100 g 250 g 500 g 1 kg 2 kg | $79.00 $174.00 $425.00 $530.00 $866.00 $1450.00 $2200.00 | 1 | |
Acetazolamide is a carbonic anhydrase inhibitor, which can affect bicarbonate and chloride transport, potentially influencing SLC26A11. | ||||||
Spironolactone | 52-01-7 | sc-204294 | 50 mg | $107.00 | 3 | |
Spironolactone, a potassium-sparing diuretic, affects aldosterone signaling and can indirectly impact chloride transport and SLC26A11. | ||||||