SLC25A21 Activators
SLC25A21 Activators are a group of chemical compounds that enhance the functional activity of the SLC25A21 protein, a mitochondrial carrier protein. These activators influence the activity of SLC25A21 either by directly interacting with the protein or by modulating the mitochondrial electrochemical gradient, a key determinant of SLC25A21 transport function. Compounds such as acetylcholine and nicotine activate nicotinic acetylcholine receptors, increasing the influx of Na+ ions and enhancing the electrochemical gradient across the mitochondrial membrane. This rise in the gradient can enhance the transport function of SLC25A21. Conversely, calcium channel blockers like nifedipine and verapamil reduce intracellular calcium concentrations. This reduction can prevent calcium-mediated inhibition of SLC25A21, indirectly enhancing its transport function.
Organic cations such as metformin, dopamine, and MPP+ can interact with SLC25A21, influencing the mitochondrial electrochemical gradient and enhancing the transport function of SLC25A21. Similarly, quinidine, known to interact with various SLC transporters, can influence the mitochondrial electrochemical gradient and enhance the transport function of SLC25A21. Proton pump inhibitors and histamine H2 receptor antagonists like omeprazole, ranitidine, and cimetidine affect the pH or electrochemical gradient across the mitochondrial membrane and could enhance the transport function of SLC25A21. Finally, clonidine, an alpha-2 adrenergic agonist, can influence the mitochondrial electrochemical gradient and enhance the transport function of SLC25A21.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine blocks calcium channels, reducing intracellular calcium concentrations. This may prevent potential calcium-mediated inhibition of SLC25A21, thereby enhancing its transport function. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $42.00 $62.00 $153.00 $255.00 $500.00 $30.00 | 37 | |
Metformin is an organic cation and its interaction with SLC25A21 can influence the mitochondrial electrochemical gradient, potentially enhancing the transport function of SLC25A21. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that reduces intracellular calcium concentrations. This can enhance the function of SLC25A21 by reducing potential calcium-mediated inhibition. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine is an organic cation and its interaction with SLC25A21 can influence the mitochondrial electrochemical gradient, potentially enhancing the transport function of SLC25A21. | ||||||
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, free base | 28289-54-5 | sc-208657 | 25 mg | $430.00 | 5 | |
MPP+ is an organic cation that can influence the mitochondrial electrochemical gradient. This influence can potentially enhance the transport function of SLC25A21. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine is known to interact with various SLC transporters. This interaction could influence the mitochondrial electrochemical gradient, potentially enhancing the transport function of SLC25A21. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Omeprazole is a proton pump inhibitor that reduces the intracellular H+ concentration. This could influence the mitochondrial electrochemical gradient and enhance the transport function of SLC25A21. | ||||||
Ranitidine | 66357-35-5 | sc-203679 | 1 g | $189.00 | ||
Ranitidine is a histamine H2 receptor antagonist that reduces gastric acid secretion. By affecting the pH gradient across the mitochondrial membrane, it could enhance the transport function of SLC25A21. | ||||||
Clonidine | 4205-90-7 | sc-501519 | 100 mg | $235.00 | 1 | |
Clonidine is an alpha-2 adrenergic agonist that can reduce the release of norepinephrine and decrease Na+ influx. This can influence the mitochondrial electrochemical gradient and enhance the transport function of SLC25A21. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
Cimetidine is a histamine H2 receptor antagonist that reduces gastric acid secretion. By affecting the pH gradient across the mitochondrial membrane, it could enhance the transport function of SLC25A21. | ||||||