SLC10A6 Activators
SLC10A6 Activators are a specialized group of chemical compounds, primarily composed of bile acids and their derivatives, that serve to enhance the SLC10A6 protein's efficacy in transporting sulfated steroids across cell membranes. Sodium taurocholate is a prime example of such an activator, directly interacting with SLC10A6 to facilitate an increased uptake of sulfated steroids, thus bolstering the protein's transport activity. Lithocholic acid and tauroursodeoxycholic acid similarly augment SLC10A6's function; they likely bind to the protein, potentially inducing a conformational change that amplifies its transport capabilities. Cholic acid and glycocholic acid further exemplify this mechanism by interacting with SLC10A6, presumably influencing the transporter's conformation and, consequently, its activity in a positive manner.
The role of SLC10A6 activators extends to include deoxycholic acid, ursodeoxycholic acid, and chenodeoxycholic acid, all of which are hypothesized to interact directly with SLC10A6, enhancing its ability to transport its substrates more efficiently. Taurochenodeoxycholic and taurolithocholic acids are thought to act as substrates themselves, potentially leading to an allosteric effect that heightens the protein's transport function. Hyodeoxycholic and glycodeoxycholic acids might also contribute to the increased activity of SLC10A6 by serving as substrates, promoting a conformational change that results in enhanced sulfated steroid transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
Lithocholic acid, another bile acid, is known to interact with SLC10A6. This compound likely increases the functional activity of SLC10A6 by binding to its substrate binding site, promoting the transport of sulfated steroids across the cell membrane. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid is a bile acid derivative that can modulate the activity of SLC10A6 by enhancing its ability to transport sulfated steroids, which may be due to an allosteric effect on the transporter, resulting in a higher affinity for its substrates. | ||||||
Cholic acid | 81-25-4 | sc-255020 sc-255020A sc-255020B sc-255020C sc-255020D | 25 g 100 g 500 g 1 kg 5 kg | $49.00 $123.00 $578.00 $1018.00 $4570.00 | 11 | |
Cholic acid is a primary bile acid that can potentially enhance the activity of SLC10A6 by increasing the transport efficiency for its substrates. The interaction between cholic acid and SLC10A6 suggests a direct effect on the transporter's conformation and activity. | ||||||
Glycocholic acid | 475-31-0 | sc-218574 sc-218574A sc-218574B sc-218574C sc-218574D sc-218574E | 100 mg 1 g 5 g 10 g 50 g 100 g | $73.00 $188.00 $680.00 $1259.00 $1675.00 $3131.00 | 4 | |
Glycocholic acid is a conjugated bile acid that may positively influence SLC10A6 activity by acting as a substrate, which could promote the overall transport function of SLC10A6, leading to enhanced substrate uptake linked to the transporter's physiological functions. | ||||||
Deoxycholic acid | 83-44-3 | sc-214865 sc-214865A sc-214865B | 5 g 25 g 1 kg | $37.00 $67.00 $941.00 | 4 | |
Deoxycholic acid, as a secondary bile acid, can activate SLC10A6 by potentially altering the transporter's substrate specificity or affinity, thereby increasing the efficiency of sulfated steroid transport. | ||||||
Ursodeoxycholic acid | 128-13-2 | sc-204935 sc-204935A | 1 g 5 g | $52.00 $131.00 | 4 | |
Ursodeoxycholic acid is known for its choleretic properties and may act on SLC10A6 by enhancing its transport capacity, potentially through a direct interaction with the protein, leading to an increased rate of substrate translocation. | ||||||
Chenodeoxycholic acid, free acid | 474-25-9 | sc-278835 sc-278835A | 1 g 5 g | $28.00 $117.00 | ||
Chenodeoxycholic acid can influence SLC10A6 by potentially increasing the transporter's substrate binding and translocation efficiency, which would result in an enhanced uptake of sulfated steroids. | ||||||
Taurolithocholic Acid Sodium Salt | 6042-32-6 | sc-208417 | 10 mg | $312.00 | ||
Taurolithocholic acid could act as an activator of SLC10A6 by binding to the transporter and facilitating the uptake of sulfated steroids, thus enhancing the transporter's physiological role in the cell. | ||||||
Glycodeoxycholic acid sodium salt | 16409-34-0 | sc-280755 | 5 g | $333.00 | 1 | |
Glycodeoxycholic acid can potentially enhance the activity of SLC10A6 by acting as a substrate for the transporter, thereby augmenting the efficiency of sulfated steroid transport and possibly influencing the transporter's specificity. | ||||||