Skint9 Inhibitors
Skint9 inhibitors are a class of chemical compounds designed to selectively target and block the function of the Skint9 protein. Skint9 is a member of the *Skint* family, a group of immunoglobulin-like proteins primarily expressed in epithelial tissues and known for their role in immune regulation, particularly in the development and function of certain types of immune cells like γδ T cells. While the specific function of Skint9 is not fully characterized, it is believed to participate in immune cell signaling, contributing to the communication between epithelial cells and immune cells. Inhibitors of Skint9 are developed to interfere with this signaling process by binding to key domains of the protein, preventing its interaction with other molecules or receptors involved in immune cell activation and regulation.
The design and study of Skint9 inhibitors require a deep understanding of the protein's structure and the molecular mechanisms through which it mediates immune signaling. Structural biology techniques, such as molecular modeling, X-ray crystallography, and computational docking, are employed to map the binding sites and conformational features of Skint9. Researchers use this information to design small molecules or other inhibitory agents that can precisely bind to these functional sites, disrupting Skint9's activity. These inhibitors are assessed through in vitro assays to determine their efficacy, specificity, and impact on Skint9-mediated signaling pathways. By studying Skint9 inhibitors, researchers aim to uncover the detailed biological roles of this protein in immune regulation and epithelial-immune cell interactions, providing insights into the broader network of proteins that modulate immune responses and maintain tissue homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Dasatinib, a tyrosine kinase inhibitor, can inhibit the activation of T-cell receptors on intraepithelial T cells 9 by inhibiting Lck, which is essential for TCR signaling. This, in turn, functionally inhibits the activity of these T cells. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
Cyclosporine binds to the cytosolic protein cyclophilin of immunocompetent lymphocytes, especially T-lymphocytes, inhibiting calcineurin which prevents the transcription of interleukin-2, a key cytokine for the activation of intraepithelial T cells 9. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin binds to FKBP12 and the complex inhibits mTOR, a key regulator of T cell proliferation and activation, leading to functional inhibition of intraepithelial T cells 9 by preventing their clonal expansion and cytokine production. | ||||||
Prednisolone | 50-24-8 | sc-205815 sc-205815A | 1 g 5 g | $82.00 $248.00 | 2 | |
Prednisolone, a glucocorticoid, induces apoptosis in activated T cells and inhibits nuclear factor kappa light chain enhancer of activated B cells (NF-κB), which is crucial for T cell activation, thereby inhibiting intraepithelial T cells 9. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib inhibits Abl tyrosine kinases which are involved in T cell receptor signaling. This disruption in signaling can functionally inhibit the activation and function of intraepithelial T cells 9. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $150.00 $920.00 | 5 | |
Sunitinib inhibits multiple receptor tyrosine kinases, some of which are involved in the signaling pathways of T cells, potentially leading to the functional inhibition of intraepithelial T cells 9. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $56.00 $260.00 $416.00 | 129 | |
Sorafenib inhibits several tyrosine protein kinases, such as VEGFR, PDGFR and Raf family kinases, which indirectly may lead to inhibition of the signaling required for the activation of intraepithelial T cells 9. | ||||||
Erlotinib, Free Base | 183321-74-6 | sc-396113 sc-396113A sc-396113B sc-396113C sc-396113D | 500 mg 1 g 5 g 10 g 100 g | $85.00 $132.00 $287.00 $495.00 $3752.00 | 42 | |
Erlotinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase, which is involved in T-cell signaling. Inhibition of EGFR can lead to functional inhibition of intraepithelial T cells 9 by altering their activation status. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $205.00 $405.00 | 9 | |
Nilotinib, a tyrosine kinase inhibitor, particularly inhibits Bcr-Abl tyrosine kinase and can functionally inhibit signaling pathways involved in the activation of intraepithelial T cells 9. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $62.00 $112.00 $214.00 $342.00 | 74 | |
Gefitinib selectively inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase, which can alter the activation and survival of T cells, leading to the functional inhibition of intraepithelial T cells 9. | ||||||