Ski2 Activators
Ski2 Activators are a group of chemical compounds that can enhance the functional activity of the Ski2 protein via specific signaling pathways or biological processes. These activators can either directly or indirectly lead to the increased functional activity of Ski2. For instance, compounds like Adenosine Triphosphate (ATP), Phosphatidylinositol 4,5-bisphosphate (PIP2), and oligoribonucleotides act by affecting the ATPase and helicase activities of Ski2, which are instrumental for its role in mRNA decay. ATP provides the energy for the unwinding of RNA duplexes while PIP2 activates the Mss116 protein, which assists Ski2 in its function. Short RNA molecules can bind to Ski2 and stimulate its helicase activity.
Another category of Ski2 activators comprises of compounds that inhibit protein phosphatases such as Sodium Orthovanadate, Staurosporine, Phenylarsine Oxide, Okadaic Acid, and Calyculin A. T Zinc and Magnesium ions can bind to Ski2 and enhance its helicase and ATPase activities, respectively. Amiloride can increase the intracellular pH, which enhances Ski2's RNA helicase activity. Guanidine Hydrochloride induces the denaturation of RNA duplexes, making it easier for Ski2 to unwind them.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP is essential for the helicase activity of Ski2, acting as a source of energy for the unwinding of RNA duplexes. Increased levels of ATP can enhance the activity of Ski2. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium Orthovanadate is a potent inhibitor of protein tyrosine phosphatases. Inhibiting these phosphatases can prevent the dephosphorylation of Ski2, maintaining its active state. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, and can enhance the activity of Ski2 by preventing the phosphorylation of proteins that could inhibit Ski2 activity. | ||||||
Phenylarsine oxide | 637-03-6 | sc-3521 | 250 mg | $41.00 | 4 | |
Phenylarsine Oxide is a potent inhibitor of protein tyrosine phosphatases. Inhibiting these phosphatases can prevent the dephosphorylation of Ski2, maintaining its active state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases, and can enhance the activity of Ski2 by preventing the dephosphorylation of Ski2, maintaining its active state. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases, and can enhance the activity of Ski2 by preventing the dephosphorylation of Ski2, maintaining its active state. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc ions can bind to the zinc finger motif of Ski2, leading to a conformational change that enhances its helicase activity. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $57.00 | 6 | |
Amiloride can increase the intracellular pH, which enhances the RNA helicase activity of Ski2. | ||||||
Guanidine Hydrochloride | 50-01-1 | sc-202637 sc-202637A sc-202637B | 100 g 1 kg 25 kg | $61.00 $310.00 $1975.00 | 1 | |
Guanidine Hydrochloride can induce the denaturation of RNA duplexes, making it easier for Ski2 to unwind them, thereby enhancing its activity. | ||||||