SIK2 Inhibitors
The chemical class of SIK2 Inhibitors, while not directly targeting SIK2, focuses on modulating kinases and pathways that interact with or are related to SIK2. SIK2, as a member of the AMPK (AMP-activated protein kinase) family, plays a role in cellular energy balance, metabolism, and other processes. The inhibitors listed predominantly target kinases within the AMPK family or related pathways. For example, HG-9-91-01, YKL-05-099, and CAY10591 target the SIK family, including SIK2, potentially affecting its kinase activity. Similarly, ARN-3236 and ARN-3261 are pan-SIK inhibitors, likely impacting SIK2 among other SIK family kinases.
Compounds like Metformin and Phenformin, known for their roles in metabolic regulation, activate AMPK, which could indirectly influence SIK2 activity. SIK2, being part of the AMPK family, may be affected by changes in AMPK activity. A-769662 and PF-06409577, both AMPK activators, could also have indirect effects on SIK2 function. Additionally, broader spectrum kinase inhibitors like Staurosporine, though not specific, may also impact SIK2 due to their wide range of kinase targets. MK-2206, an AKT inhibitor, and Rapamycin, an mTOR inhibitor, influence various signaling pathways, potentially including those where SIK2 is involved, given the interconnected nature of kinase signaling networks.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that can inhibit a wide range of kinases, potentially including SIK2. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
1,1-Dimethylbiguanide, Hydrochloride, primarily known for its antidiabetic properties, can indirectly affect SIK2 activity through AMPK-related pathways, as SIK2 is a part of the AMPK kinase family. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A-769662 is an AMPK activator. By influencing AMPK activity, it can indirectly affect SIK2, which is a member of the AMPK kinase family. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin is an antidiabetic drug that activates AMPK. It could indirectly affect SIK2 activity, considering SIK2's role in the AMPK kinase family. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $182.00 $332.00 | 67 | |
MK-2206 is an allosteric inhibitor of AKT, a kinase that interacts with various cellular pathways, potentially influencing pathways where SIK2 is involved. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. Since mTOR interacts with multiple kinase pathways, including those involving SIK2, its inhibition can have indirect effects on SIK2 function. | ||||||