SHOX2A Inhibitors
SHOX2A inhibitors represent a class of chemical compounds designed to specifically target and modulate the activity of the SHOX2A protein, which belongs to the homeobox gene family. SHOX2A plays a crucial role in the regulation of skeletal development, particularly in bone growth and maintenance. Its significance lies in its involvement in the determination of body height, as mutations or dysregulation of SHOX2A have been associated with short stature and certain skeletal disorders.
The mechanism of action of SHOX2A inhibitors typically involves interfering with the function of the SHOX2A protein. While the specific mechanisms may vary depending on the inhibitor, many aim to disrupt the binding of SHOX2A to its DNA target sites or alter its interactions with co-factors and transcriptional regulators. By inhibiting SHOX2A, these compounds may modulate the expression of downstream target genes involved in bone development. Research in this area is ongoing, as understanding the intricate regulatory pathways governed by SHOX2A is essential for uncovering applications in the context of skeletal and growth-related disorders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $209.00 $312.00 $620.00 $1026.00 | 2 | |
Inhibits the phosphorylation of SOX2, which is required for its transcriptional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Binds to the SOX2 protein and prevents it from binding to DNA. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Inhibits the interaction of SOX2 with the transcription factor β-catenin, preventing the formation of the SOX2-β-catenin complex, which is essential for SOX2-mediated transcription. | ||||||
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
Binds to the SOX2 protein and prevents it from binding to DNA. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Binds to the SOX2 protein and prevents it from binding to DNA. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Inhibits the expression of the SOX2 gene. | ||||||
Tanshinone IIA | 568-72-9 | sc-200932 sc-200932A | 5 mg 25 mg | $86.00 $310.00 | 22 | |
Binds to the SOX2 protein and prevents it from binding to DNA. | ||||||