SHISA4 Inhibitors
Chemical inhibitors of SHISA4 include a range of compounds that interfere with voltage-gated ion channels, which are critical to the role of SHISA4 in stabilizing the inactive states of these channels in neurons. Dihydroquinidine, for instance, blocks voltage-gated calcium channels, directly inhibiting the ability of SHISA4 to stabilize these channels in their inactive state. Similarly, phenytoin, which acts as a voltage-gated sodium channel inhibitor, would prevent SHISA4 from exerting its stabilizing influence on these channels. Other sodium channel inhibitors such as lamotrigine and carbamazepine would also prevent SHISA4 from maintaining sodium channels in an inactive state, thereby inhibiting the protein's function. Tetrodotoxin, a potent and specific blocker of voltage-gated sodium channels, would further inhibit SHISA4's capacity to stabilize these channels, significantly impacting the protein's function in neuronal signaling.
Calcium channel blockers present another mechanism by which SHISA4's function can be inhibited. Mibefradil targets T-type calcium channels, while nimodipine, nifedipine, amlodipine, and verapamil, which are specific for L-type calcium channels, can prevent SHISA4 from affecting these channels' inactive state stabilization. This blocking of the calcium channels would directly inhibit SHISA4's role in modulating neuronal excitability. Gabapentin, which binds to the auxiliary subunit of voltage-gated calcium channels, could also interfere with SHISA4's interaction with these subunits and thus its ability to modulate channel activity. Finally, oxcarbazepine, another sodium channel blocker, would inhibit SHISA4's stabilizing effect on these channels, effectively inhibiting the protein's function in the complex processes of neuronal excitability and signaling.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5,5-Diphenyl Hydantoin | 57-41-0 | sc-210385 | 5 g | $70.00 | ||
Phenytoin acts as a voltage-gated sodium channel inhibitor. Since SHISA4 is implicated in the stabilization of the inactive states of voltage-gated channels, phenytoin would inhibit this stabilization activity of SHISA4 by keeping the sodium channels in an inhibited state, thereby preventing SHISA4 from exerting its effect on these channels. | ||||||
Mibefradil dihydrochloride | 116666-63-8 | sc-204083 sc-204083A | 10 mg 50 mg | $209.00 $848.00 | 4 | |
Mibefradil is a T-type calcium channel blocker. It inhibits low-threshold calcium channels, which may be stabilized in their inactive form by SHISA4. By blocking these specific channels, mibefradil could inhibit any facilitatory function SHISA4 might have on the channels, thus functionally inhibiting SHISA4's role in modulating neuronal excitability. | ||||||
Lamotrigine | 84057-84-1 | sc-201079 sc-201079A | 10 mg 50 mg | $118.00 $476.00 | 1 | |
Lamotrigine is known to inhibit voltage-sensitive sodium channels, hence decreasing presynaptic neurotransmitter release. Since SHISA4 functions to stabilize the inactive states of voltage-gated channels, lamotrigine would inhibit SHISA4's ability to modulate these channels by maintaining them in an inactive state, which would inhibit the action of SHISA4 on neuronal signaling. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $60.00 $301.00 | 2 | |
Nimodipine selectively inhibits L-type calcium channels. SHISA4's role in stabilizing the inactive state of voltage-gated channels would be inhibited by nimodipine's action, preventing SHISA4 from affecting these calcium channels and thus inhibiting its function. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
Nifedipine, another L-type calcium channel blocker, would inhibit the effect of SHISA4 on these channels by maintaining them in a blocked state, thereby inhibiting the functional role of SHISA4 in facilitating the stabilization of these channels' inactive states. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $73.00 $163.00 | 2 | |
Amlodipine is an L-type calcium channel blocker and would inhibit SHISA4 by blocking the channels SHISA4 is thought to stabilize in their inactive states, thereby inhibiting the functional effects of SHISA4 on neuronal excitability and neurotransmission. | ||||||
Gabapentin | 60142-96-3 | sc-201481 sc-201481A sc-201481B | 20 mg 100 mg 1 g | $52.00 $92.00 $132.00 | 7 | |
Gabapentin binds to the auxiliary subunit of voltage-gated calcium channels, which could interfere with the function of SHISA4 if SHISA4 interacts with this subunit to exert its effects. Thus, gabapentin could inhibit the functional impact of SHISA4 on these channels. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a phenylalkylamine L-type calcium channel blocker which would inhibit SHISA4's function by blocking the calcium channels that SHISA4 is involved in stabilizing, thus inhibiting the protein's ability to modulate neuronal signaling through these channels. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $32.00 $70.00 | 5 | |
Carbamazepine inhibits sodium channels and would thus inhibit SHISA4 by preventing the stabilization of the inactive state of these channels, which is the functional role attributed to SHISA4. | ||||||