Shd Activators represent a distinctive class of chemical compounds characterized by their ability to modulate the activity of the Shd signaling pathway within biological systems. The Shd pathway, short for Signal transduction by Helical Domains, is an intricate cellular communication network crucial for various physiological processes. Shd activators specifically target and enhance the transduction of signals along this pathway, facilitating the transmission of intracellular messages. These activators typically interact with specific components of the Shd pathway, often through allosteric binding or enzymatic modulation, leading to a cascade of molecular events that amplify the cellular response. The mechanism of action of Shd activators involves their ability to induce conformational changes in the Shd proteins, consequently fine-tuning the transmission of signals and influencing downstream cellular activities.
Chemically, Shd activators exhibit structural diversity, comprising compounds with distinct molecular scaffolds and functional groups. Researchers have identified a range of synthetic and naturally occurring molecules that fall under the umbrella of Shd activators, showcasing the versatility of this chemical class. The development of selective Shd activators has opened avenues for exploring the intricate regulation of cellular processes governed by the Shd pathway. As scientists continue to unravel the complexities of signal transduction, Shd activators serve as valuable tools in elucidating the roles of the Shd pathway in various cellular contexts, contributing to a deeper understanding of fundamental biological mechanisms.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin receptor activation promotes the activation of PI3K/Akt signaling, which indirectly enhances the activity of Shd by increasing cellular PIP3 levels. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin binds to calcium ions and becomes activated, which can then interact with various kinases that phosphorylate and enhance the activity of Shd. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate Shd, leading to its enhanced functional activity in signaling pathways. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases cAMP levels, leading to the activation of PKA. PKA can phosphorylate Shd, enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which activates calmodulin-dependent kinases that can phosphorylate Shd and enhance its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, which indirectly prevents the inhibition of signal transduction pathways that Shd is involved in, enhancing its activity. | ||||||