Sgo1 Inhibitors
Sgo1 inhibitors belong to a distinctive chemical class known for their specific molecular interactions with the target protein, Shugoshin 1 (Sgo1). Shugoshins are crucial regulatory proteins involved in ensuring proper chromosome segregation during cell division, particularly in the process of mitosis. Sgo1, a key member of this protein family, plays a pivotal role in safeguarding the fidelity of cell division by hindering premature separation of sister chromatids. The inhibitors designed to target Sgo1 operate by disrupting its normal function, thereby modulating the intricate molecular machinery governing chromosomal stability.
Structurally, Sgo1 inhibitors possess distinctive chemical features that enable them to bind selectively to the active sites or binding pockets on the Sgo1 protein. The binding interactions between the inhibitor molecules and specific regions of Sgo1 influence the protein's conformation and interfere with its ability to perform its regulatory function. Through this targeted disruption, Sgo1 inhibitors contribute to the controlled regulation of the mitotic process, with potential implications in understanding the fundamental biology of cell division. Researchers are keenly exploring the structural nuances and biochemical intricacies of Sgo1 inhibitors to unravel their precise mechanism of action and how they might be harnessed for various applications in the realm of cellular and molecular biology.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a known inhibitor of the kinesin Eg5 which is involved in spindle formation during mitosis. By disrupting spindle dynamics, it can indirectly affect SGO1's role in chromosome segregation. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules and thereby can interfere with the dynamics necessary for chromosome segregation where SGO1 plays a protective role. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
An agent that destabilizes microtubules, nocodazole can disrupt mitotic spindle formation and potentially interfere with SGO1's function in chromosome protection and segregation. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
This Plk1 inhibitor can disrupt polo-like kinase 1 activity, a kinase that has been implicated in the proper function of SGO1 during mitosis. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor that would interfere with the phosphorylation events necessary for proper chromosome alignment and segregation where SGO1 is involved. | ||||||
Hesperadin | 422513-13-1 | sc-490384 | 10 mg | $304.00 | ||
Inhibitor of Aurora B kinase which affects chromosome alignment and segregation, processes in which SGO1 is implicated to ensure proper chromosomal movement. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
A pan-Aurora kinase inhibitor that could disrupt several processes in mitosis, potentially affecting SGO1's function in ensuring proper chromosome cohesion and segregation. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
An inhibitor of JNK, which has been shown to phosphorylate proteins involved in mitotic progression, potentially affecting SGO1's functional role indirectly. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
A checkpoint kinase inhibitor that can interfere with cell cycle progression, and thus could indirectly influence SGO1's role in chromosome segregation. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
A CDK4/6 inhibitor which is known to regulate the cell cycle, potentially affecting SGO1's role by altering the timing and regulation of mitosis. | ||||||