SFTPG Inhibitors
Chemical inhibitors of SFTPG operate through various mechanisms to disrupt its function. Alisertib targets Aurora kinase A, a protein important for the regulation of mitosis. By inhibiting this kinase, Alisertib can interfere with cell division processes that are crucial for the proper functioning of SFTPG. Paclitaxel, on the other hand, works by stabilizing microtubules, preventing their disassembly which is also essential during cell division. This stabilization can inadvertently affect the function of SFTPG, given the protein's roles during these cellular processes. Bortezomib introduces a different mode of action as a proteasome inhibitor. By preventing the breakdown of misfolded proteins, it can induce cellular stress responses that can interfere with the function of a broad range of proteins, including SFTPG. Rapamycin, known for its role as an mTOR inhibitor, can downregulate protein synthesis overall, which can lead to a reduction in the functioning of proteins like SFTPG.
Furthermore, Lenalidomide and Thalidomide engage with the cellular machinery by modulating the ubiquitin-proteasome pathway, which is responsible for protein turnover. This modulation can alter the function of proteins like SFTPG by affecting their stability and signaling. Histone deacetylase inhibitors such as Vorinostat and Trichostatin A change the expression patterns of genes and the function of various proteins, which can lead to alterations in SFTPG function. Zoledronic Acid, by inhibiting farnesyl pyrophosphate synthase, affects the mevalonate pathway and thus, can influence a wide array of cellular functions including those involving SFTPG. Tunicamycin, which inhibits N-linked glycosylation, affects post-translational modification that is vital for the function of many proteins, potentially impacting SFTPG as well. Monensin disrupts ion gradients and can perturb membrane functions, thereby influencing membrane-associated proteins such as SFTPG. Lastly, Cycloheximide interferes with protein synthesis, which can directly inhibit the biosynthesis and subsequent function of SFTPG. Each chemical, through its distinct mechanism, can contribute to the inhibition of SFTPG, reflecting the complex interplay between small molecules and protein function within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Alisertib is an Aurora kinase A inhibitor. Aurora kinase A is involved in the regulation of mitosis. Inhibition of this kinase by Alisertib can disrupt mitotic processes, potentially leading to the functional inhibition of SFTPG, given that SFTPG is implicated in membrane processes that may be affected during mitosis. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can inhibit cell division. Since SFTPG is involved in cellular processes that are active during cell division, the stabilization of microtubules can lead to its functional inhibition. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor that can lead to the accumulation of misfolded proteins in the cell, triggering cellular stress responses that could inhibit the functional activity of SFTPG as part of a broader cellular response to proteostatic stress. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. Inhibition of the mTOR pathway can result in reduced protein synthesis and cell proliferation. SFTPG, being a protein involved in cellular functioning, could be functionally inhibited as a consequence of the general downregulation of protein synthesis. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Lenalidomide has immunomodulatory effects and can influence the ubiquitin-proteasome pathway. In doing so, it can indirectly inhibit the function of SFTPG by disrupting the protein turnover and signaling pathways that SFTPG may be involved in. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Thalidomide, like Lenalidomide, affects multiple cellular processes including the ubiquitin-proteasome pathway and can thus disrupt the protein homeostasis within the cell potentially leading to the functional inhibition of SFTPG. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor. By altering the acetylation status of histones and other proteins, it can change the expression patterns of genes and the function of proteins. SFTPG function could be inhibited as a result of these widespread changes in protein function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, another histone deacetylase inhibitor, can similarly alter protein function and gene expression patterns, which could lead to the functional inhibition of SFTPG due to changes in the cellular environment. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic Acid is a bisphosphonate that inhibits farnesyl pyrophosphate synthase. This enzyme is involved in the mevalonate pathway, which is crucial for various cellular processes. Inhibition of this pathway can result in a broad inhibition of cellular functions, including those related to SFTPG. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation. As glycosylation is a post-translational modification essential for the proper function of many proteins, its inhibition can lead to the functional inhibition of proteins like SFTPG that may rely on glycosylation. | ||||||