SERCA Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA), uniquely disrupting calcium homeostasis within cells. It binds irreversibly to the enzyme, inducing a conformational change that prevents calcium transport. This interaction leads to elevated cytosolic calcium levels, triggering various signaling pathways. The compound's specificity for SERCA is attributed to its unique structural features, which facilitate strong binding and alter the enzyme's kinetic properties, ultimately affecting cellular calcium dynamics. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $66.00 | 4 | |
t-Butylhydroquinone acts as a selective modulator of SERCA, influencing calcium ion transport through reversible binding. Its unique molecular structure allows for specific interactions with the enzyme, stabilizing certain conformations that enhance calcium uptake efficiency. This compound alters reaction kinetics by affecting the enzyme's affinity for calcium, leading to nuanced changes in intracellular calcium signaling. Its distinct hydrophobic properties also contribute to its interaction dynamics within lipid membranes. | ||||||
Paxilline | 57186-25-1 | sc-3588 sc-3588A | 5 mg 25 mg | $253.00 $924.00 | 14 | |
Paxilline is a potent inhibitor of SERCA, characterized by its ability to disrupt calcium ion transport through specific binding interactions. Its unique molecular architecture facilitates selective engagement with the enzyme, altering its conformational states and impacting calcium affinity. This modulation affects the kinetics of calcium translocation, leading to significant alterations in cellular calcium homeostasis. Additionally, Paxilline's hydrophobic characteristics enhance its integration into lipid environments, influencing membrane dynamics. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium red is a selective inhibitor of SERCA, known for its unique ability to bind to the enzyme's regulatory sites, thereby modulating calcium ion transport. Its distinct coordination chemistry allows for specific interactions with the enzyme's active site, influencing the conformational dynamics essential for calcium translocation. This compound exhibits notable stability in various environments, which can affect its interaction kinetics and overall impact on cellular calcium regulation. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic Acid is a potent inhibitor of SERCA, characterized by its ability to disrupt calcium ion homeostasis. It interacts with the enzyme's transmembrane domains, altering the conformational states necessary for calcium transport. This compound exhibits unique binding kinetics, leading to a prolonged inhibition effect. Its structural features facilitate specific interactions that can modulate the enzyme's activity, impacting cellular calcium signaling pathways. | ||||||
Gingerol | 23513-14-6 | sc-201519 sc-201519A | 5 mg 20 mg | $107.00 $379.00 | 5 | |
Gingerol acts as a modulator of SERCA by influencing calcium ion transport dynamics. Its unique molecular structure allows for specific interactions with the enzyme's active site, promoting conformational changes that enhance calcium affinity. The compound exhibits distinct reaction kinetics, characterized by a rapid association and slower dissociation, which can lead to sustained effects on calcium cycling. This modulation can significantly impact cellular signaling and metabolic processes. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $113.00 $454.00 | 3 | |
CGP 37157 functions as a potent inhibitor of SERCA, selectively disrupting calcium ion reuptake in the sarcoplasmic reticulum. Its unique binding affinity alters the enzyme's conformational state, leading to a decrease in calcium transport efficiency. The compound exhibits a distinctive kinetic profile, with a notable delay in the onset of inhibition, allowing for transient calcium elevation. This modulation of calcium homeostasis can influence various intracellular signaling pathways and cellular excitability. | ||||||
2,5-Di-tert-butylhydroquinone (DBHQ) | 88-58-4 | sc-201516 sc-201516A | 25 g 1 kg | $34.00 $169.00 | 1 | |
2,5-Di-tert-butylhydroquinone (DBHQ) acts as a selective modulator of SERCA, impacting calcium ion dynamics within the cell. Its unique molecular structure facilitates specific interactions with the enzyme, altering its activity and influencing calcium transport rates. DBHQ exhibits a distinct reaction kinetics profile, characterized by a gradual onset of inhibition, which can lead to transient fluctuations in intracellular calcium levels. This modulation can significantly affect cellular signaling and metabolic processes. | ||||||