Molecular structure of 2,5-Di-tert-butylhydroquinone (DBHQ), CAS Number: 88-58-4
2,5-Di-tert-butylhydroquinone (DBHQ) (CAS 88-58-4)
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Alternate Names:
DTBHQ; 2,5-Di-tert-butyl-1,4-hydroquinone
Application:
2,5-Di-tert-butylhydroquinone (DBHQ) is an inducer of Ca2+
CAS Number:
88-58-4
Purity:
99%
Molecular Weight:
222.3
Molecular Formula:
C14H22O2
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2,5-Di-tert-butylhydroquinone (DBHQ) has been shown to be a selective and potent inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which is shown to cause induction of Ca2+ release from agonist-insensitive and agonist-sensitive intracellular stores. In isolated rat hepatocyte studies, DBHQ was reported to induce a rapid increase in cytosolic Ca2+ concentration without loss of other microsomal enzyme activity, altering membrane permeability, or modification of microsomal protein thiols.
2,5-Di-tert-butylhydroquinone (DBHQ) (CAS 88-58-4) References
- Depletion of the inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ store in vascular endothelial cells activates the agonist-sensitive Ca(2+)-influx pathway. | Schilling, WP., et al. 1992. Biochem J. 284 (Pt 2): 521-30. PMID: 1318033
- A role for ERK1/2 in EGF- and ATP-dependent regulation of amiloride-sensitive sodium absorption. | Falin, R., et al. 2005. Am J Physiol Cell Physiol. 288: C1003-11. PMID: 15634742
- Agonist-sensitive and -insensitive intracellular Ca2+ pools. Separate Ca(2+)-releasing mechanisms revealed by manoalide and benzohydroquinone. | Muallem, S., et al. 1991. Biochem J. 279 (Pt 2): 367-75. PMID: 1659378
- Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes. | Mason, MJ., et al. 1991. J Biol Chem. 266: 20856-62. PMID: 1834651
- Development of a fluorescent chelating ligand for gallium ion having a quinazoline structure with two Schiff base moieties. | Kimura, J., et al. 2009. Anal Chim Acta. 635: 207-13. PMID: 19216880
- 2,5-Di(tert-butyl)-1,4-benzohydroquinone--a novel inhibitor of liver microsomal Ca2+ sequestration. | Moore, GA., et al. 1987. FEBS Lett. 224: 331-6. PMID: 2961610
- Hydrogen-Bond-Assisted Solution Discharge in Aprotic Li-O2 Batteries. | Xiong, Q., et al. 2022. Adv Mater. 34: e2110416. PMID: 35363905
- Hydroquinone derivatives attenuate biofilm formation and virulence factor production in Vibrio spp. | Sathiyamoorthi, E., et al. 2023. Int J Food Microbiol. 384: 109954. PMID: 36257185
- Calcium- and CaMKII-dependent chloride secretion induced by the microsomal Ca(2+)-ATPase inhibitor 2,5-di-(tert-butyl)-1,4-hydroquinone in cystic fibrosis pancreatic epithelial cells. | Chao, AC., et al. 1995. J Clin Invest. 96: 1794-801. PMID: 7560071
- Interactions of dihydroxybenzenes with the Ca(2+)-ATPase: separate binding sites for dihydroxybenzenes and sesquiterpene lactones. | Khan, YM., et al. 1995. Biochemistry. 34: 14385-93. PMID: 7578042
- Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells. | Charlesworth, A. and Rozengurt, E. 1994. J Biol Chem. 269: 32528-35. PMID: 7798254
- Intracellular Ca2+ pool content is linked to control of cell growth. | Short, AD., et al. 1993. Proc Natl Acad Sci U S A. 90: 4986-90. PMID: 8389460
- Pinocytosis in 2,5-di-tert-butylhydroquinone-stimulated hepatocytes and evaluation of its role in Ca2+ inflow. | Fernando, KC. and Barritt, GJ. 1996. Mol Cell Biochem. 162: 23-9. PMID: 8905622
Inhibitor of:
SERCA.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2,5-Di-tert-butylhydroquinone (DBHQ), 25 g | sc-201516 | 25 g | $34.00 | |||
2,5-Di-tert-butylhydroquinone (DBHQ), 1 kg | sc-201516A | 1 kg | $169.00 |