SEMA3B Activators
SEMA3B activators belong to a specialized class of chemical compounds that play a pivotal role in modulating the activity of SEMA3B, a member of the semaphorin family of proteins. Semaphorins are a diverse group of secreted and membrane-bound proteins that were initially characterized for their role in axonal guidance during neural development. SEMA3B, specifically, is classified as a class 3 semaphorin and is known to participate in various biological processes, including neuronal development, immune responses, and cancer progression. SEMA3B activators are small molecules or biologics designed to enhance the functional activity of SEMA3B or its downstream signaling pathways.
At a molecular level, SEMA3B activators exert their effects by binding to SEMA3B or its associated receptors, thereby modulating the semaphorin signaling cascade. This class of compounds may enhance the ability of SEMA3B to mediate cell-to-cell communication, particularly in the context of axonal guidance and cell migration. By doing so, SEMA3B activators have the potential to influence processes like neuronal pathfinding during development and immune cell movement during inflammatory responses. Furthermore, these activators might also impact cancer cell behavior, as SEMA3B has been implicated in regulating tumor progression and metastasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an HDAC inhibitor that can directly activate SEMA3B and increase its expression by promoting histone acetylation. It may also indirectly impact related pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a protein kinase inhibitor that may indirectly influence SEMA3B by altering signaling cascades within related pathways, potentially leading to increased gene expression. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl Cyclic AMP (dbcAMP) can directly affect gene expression through PKA and downstream effectors, potentially leading to increased SEMA3B expression and related pathway modulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is an HDAC inhibitor that can directly increase SEMA3B expression by altering histone acetylation. It may also impact related pathways through this mechanism. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that may directly impact SEMA3B and increase its expression by inhibiting mTOR signaling. It may also affect downstream gene expression within related pathways. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can directly impact SEMA3B and increase its expression by inhibiting PI3Ks, potentially influencing downstream gene expression within related pathways. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 is an NF-κB inhibitor that may directly or indirectly affect gene expression, including SEMA3B, by inhibiting NF-κB, although SEMA3B regulation by NF-κB is not well-established. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
Rosiglitazone is a PPAR agonist that can directly influence SEMA3B and increase its expression by modulating the expression of genes involved in various cellular processes, including those related to SEMA3B and its associated pathways. | ||||||