SEMA3A Inhibitors

Common SEMA3A Inhibitors include, but are not limited to Sunitinib, Free Base CAS 557795-19-4, 2-Methoxyestradiol CAS 362-07-2, VEGFR2 Kinase Inhibitor I CAS 15966-93-5, AZD1480 CAS 935666-88-9 and BIBF1120 CAS 656247-17-5.

SEMA3A inhibitors belong to a chemical class designed to interact with and modulate the activity of SEMA3A, which is a secreted protein belonging to the semaphorin family. SEMA3A plays a critical role in various biological processes, particularly in axon guidance and neural development. It functions as a repulsive guidance cue, helping to guide developing axons by regulating their growth and pathfinding. By binding to its receptors on the surface of growth cones, SEMA3A provides crucial cues that steer axons away from inappropriate areas, ensuring accurate neural circuit formation.

Inhibiting SEMA3A involves disrupting its interactions with its receptors, thereby affecting the guidance cues provided to growing axons. By exploring the effects of SEMA3A inhibitors, researchers aim to gain deeper insights into the complex molecular mechanisms that underlie neural development and axon guidance. This research contributes to our understanding of how neural circuits are formed during development and how abnormalities in these processes can lead to neurological disorders. Additionally, the study of SEMA3A inhibitors sheds light on the broader role of semaphorin family proteins in various biological contexts beyond neural development, unveiling applications in different fields of biology.