Molecular structure of VEGFR2 Kinase Inhibitor I, CAS Number: 15966-93-5
VEGFR2 Kinase Inhibitor I (CAS 15966-93-5)
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Application:
VEGFR2 Kinase Inhibitor I is a highly selective and cell-permeable tyrosine kinase inhibitor
CAS Number:
15966-93-5
Purity:
>95%
Molecular Weight:
310.4
Molecular Formula:
C18H18N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
VEGFR2 Kinase Inhibitor I is a highly selective, cell-permeable indolin-2-one class of receptor tyrosine kinase (RTK) inhibitor (IC50 = 70 nM) for murine vascular endothelial growth factor receptor 2 (VEGF-R2; KDR/Flk-1). The inhibition is suggested to be competitive with respect to ATP. VEGFR2 Kinase Inhibitor I has been shown to not inhibit PDGF, EGF, and IGF-1 RTK activities (IC50 > 100 µM).
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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VEGFR2 Kinase Inhibitor I (CAS 15966-93-5) References
- Expression of angiopoietins in renal epithelial and clear cell carcinoma cells: regulation by hypoxia and participation in angiogenesis. | Yamakawa, M., et al. 2004. Am J Physiol Renal Physiol. 287: F649-57. PMID: 15198927
- HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle. | Milkiewicz, M., et al. 2007. J Physiol. 583: 753-66. PMID: 17627993
- p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis. | Gee, E., et al. 2010. J Cell Physiol. 222: 120-6. PMID: 19774558
- Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2. | Mitola, S., et al. 2010. Blood. 116: 3677-80. PMID: 20660291
- Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials. | Korbee, CJ., et al. 2018. Nat Commun. 9: 358. PMID: 29367740
- Tumor necrosis factor receptor-2 signaling pathways promote survival of cancer stem-like CD133+ cells in clear cell renal carcinoma. | Bradley, JR., et al. 2020. FASEB Bioadv. 2: 126-144. PMID: 32123862
- MAZ51 Blocks the Tumor Growth of Prostate Cancer by Inhibiting Vascular Endothelial Growth Factor Receptor 3. | Yamamura, A., et al. 2021. Front Pharmacol. 12: 667474. PMID: 33959030
- Thrombolytic tPA-induced hemorrhagic transformation of ischemic stroke is mediated by PKCβ phosphorylation of occludin. | Goncalves, A., et al. 2022. Blood. 140: 388-400. PMID: 35576527
- Terminally Exhausted CD8+ T Cells Resistant to PD-1 Blockade Promote Generation and Maintenance of Aggressive Cancer Stem Cells. | Chakravarti, M., et al. 2023. Cancer Res. 83: 1815-1833. PMID: 36971604
- Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. | Sun, L., et al. 1998. J Med Chem. 41: 2588-603. PMID: 9651163
Inhibitor of:
Flk-1, SEMA3A, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VEGFR2 Kinase Inhibitor I, 1 mg | sc-202850 | 1 mg | $150.00 |