Sec61α2 Inhibitors

Sec61α2 inhibitors constitute a chemical class of compounds that and reversibly target Sec61α2, which is the alpha subunit isoform 2 of the Sec61 protein translocation channel in the endoplasmic reticulum (ER). Sec61α2 plays a crucial role in the translocation of proteins into the ER lumen. These inhibitors are specifically engineered to interact with Sec61α2, aiming to disrupt its function in protein translocation through the Sec61 translocon. The chemical structure of Sec61α2 inhibitors enables them to bind to specific regions or binding sites on Sec61α2, potentially hindering its ability to facilitate the translocation of proteins across the ER membrane. Researchers employ Sec61α2 inhibitors in biochemical and cellular studies to unravel the intricacies of Sec61α2's role in protein translocation and its implications in cellular processes. The design and development of these inhibitors rely on a comprehensive understanding of Sec61α2's structural features and its involvement in the ER protein translocation pathway, providing valuable tools for advancing research in the field of cellular protein regulation and translocation processes.