SEC11C Inhibitors
The SEC11C protein itself is part of the endoplasmic reticulum (ER)-localized signal peptidase complex, involved in cleaving signal peptides from nascent proteins as they are translocated into the ER. Given its specialized role, substances that are known to inhibit or affect SEC11C activity are usually broad-spectrum compounds that have a more general effect on various cellular pathways, including protein synthesis, ER function, and intracellular transport. These compounds may include everything from substances affecting ion balances, like ionophores, to more generalized inhibitors of cellular transport mechanisms. For example, inhibitors like Brefeldin A and Wortmannin don't directly target SEC11C but rather inhibit upstream or associated processes, affecting SEC11C activity indirectly.
Interestingly, the compounds that affect SEC11C are generally classified under different types of chemical inhibitors based on their primary targets and mechanisms of action. Brefeldin A, for instance, is categorized as a disruptor of ER-Golgi transport, and Wortmannin is a well-known phosphoinositide 3-kinase (PI3K) inhibitor. This lack of specificity poses a challenge in elucidating the specific biological roles and regulatory pathways involving SEC11C. Moreover, most of the existing compounds known to affect SEC11C are not categorized as SEC11C inhibitors due to their broad spectrum of activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits the movement of secretory proteins from the endoplasmic reticulum to the Golgi apparatus, disrupting SEC11C activity indirectly. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, and by affecting this pathway, it can indirectly impact SEC11C functions involved in protein secretion. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide inhibits protein synthesis at the translocation step, affecting SEC11C indirectly by reducing the number of proteins that reach it for processing. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin elevates cytosolic calcium levels by inhibiting ER calcium ATPases. This indirectly influences SEC11C by disrupting calcium-dependent processes in the ER. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin blocks the initial step of glycosylation in the ER, indirectly affecting the function of SEC11C by modifying the proteins it encounters. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $114.00 $203.00 $354.00 $697.00 $1363.00 $5836.00 | 12 | |
Eeyarestatin I inhibits endoplasmic reticulum-associated protein degradation (ERAD), indirectly affecting SEC11C by disrupting the quality control and export of proteins from the ER. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule formation, indirectly affecting SEC11C by inhibiting the transportation of vesicles between the ER and Golgi. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a lysosomotropic agent that raises intracellular pH, affecting lysosome function. This can indirectly affect SEC11C activity by altering endocytic pathways. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Valinomycin acts as a potassium ionophore, disrupting ion gradients across membranes. This can indirectly affect SEC11C by altering the electrochemical conditions in the ER. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that disrupts ion gradients, potentially affecting SEC11C indirectly by altering electrochemical conditions necessary for its activity. | ||||||