SCOP Activators
SCOP activators are considered as compounds that might indirectly influence the functional activity or expression of SCOP through various cellular mechanisms and signaling pathways modulation. Given SCOP's role in regulating Akt signaling and other cellular processes, compounds that perturb the balance of phosphatase and kinase activities, such as Okadaic Acid and Calyculin A, might indirectly impact the functional landscape in which SCOP operates. Changes in intracellular cAMP levels induced by agents like Forskolin or alterations in PI3K/Akt signaling through LY 294002 could create a cellular environment that alters the demand or activity of SCOP, especially in its role as a negative regulator of these pathways. Inhibitors of major signaling pathways such as Rapamycin, Lithium Chloride, U0126, and SB 203580 might indirectly influence SCOP activity by changing the cellular signaling dynamics and requirements for regulation, especially in pathways related to cell growth, apoptosis, and metabolism. Broad-spectrum kinase inhibitors like Sunitinib, Free Base, as well as agents affecting cell cycle dynamics such as Hydroxyurea, might also alter the cellular context and thus the functional relevance or activity of SCOP.
Furthermore, changes in the cellular protein stability environment, induced by proteasome inhibitors, or shifts in gene expression patterns due to compounds like Sodium Butyrate, could indirectly modify the activity or expression of SCOP. These compounds, through their varied and sometimes broad effects, highlight the complex nature of cellular signaling and regulation, and the potential indirect strategies that might influence the activity of a specific phosphatase like SCOP within these networks. Each compound, by altering different aspects of cellular physiology, could contribute to the modulation of SCOP, reflecting the interplay of multiple signaling pathways and regulatory mechanisms essential for maintaining cellular homeostasis and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. While not directly an activator of SCOP, modulation of the phosphatase activity in cells can indirectly influence SCOP's relative activity or prominence in certain signaling pathways, particularly in studying its regulatory roles. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is another inhibitor of protein phosphatases. By perturbing the overall balance of phosphatase and kinase activity in cells, Calyculin A might indirectly affect the functional context in which SCOP operates, potentially altering its activity or the reliance on its function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates intracellular cAMP levels, which can lead to the activation of PKA. While Forskolin itself doesn't directly activate SCOP, changes in PKA activity and subsequent signaling cascades might alter the cellular context and demand for SCOP's regulatory activities. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit GSK-3β, a kinase involved in numerous signaling pathways. By modulating pathways associated with GSK-3β, Lithium Chloride might indirectly affect the signaling context and activity of SCOP. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a specific inhibitor of p38 MAP kinase. By inhibiting p38 MAPK signaling, it might indirectly affect the cellular context in which SCOP operates, potentially altering its functional demand or activity. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib, Free Base is a receptor tyrosine kinase inhibitor and affects various signaling pathways. Its broad action on signaling might indirectly influence SCOP activity or expression by altering the cellular signaling environment. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea is used to induce cell cycle arrest and can affect DNA synthesis. By altering cell cycle dynamics, it may indirectly impact the demand or relevance of SCOP's activity in cell cycle regulation or other processes. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitors like MG-132 [Z-Leu- Leu-Leu-CHO] increase the levels of ubiquitinated proteins and can lead to stress responses. This might indirectly influence the activity or stability of SCOP by altering the cellular environment. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate is a histone deacetylase inhibitor and can affect gene expression. It might indirectly influence SCOP activity by altering the expression of proteins involved in the signaling pathways where SCOP functions. | ||||||