SCaMC-1 Activators
SCaMC-1 activators play a pivotal role in the modulation of mitochondrial calcium transport. Calcium ions are fundamental to a plethora of cellular processes, and a precise regulation of their mitochondrial uptake is essential for maintaining cellular homeostasis. Many of the SCaMC-1 activators function through modulating cytosolic calcium levels. For instance, Calcimycin, being an ionophore, promotes calcium influx into the cytosol. A surge in cytosolic calcium concentrations demands compensatory mechanisms to restore balance, one of which involves transporting excess calcium into the mitochondria, a process mediated by SCaMC-1. Similarly, agents like Thapsigargin and BHQ exert their effects by inhibiting the SERCA pump. The consequential elevation in cytosolic calcium levels places a demand on SCaMC-1, thereby potentially enhancing its activity.
Another modality involves calcium channel blockers such as Nifedipine and Verapamil. These agents, by altering the dynamics of calcium influx, can indirectly influence SCaMC-1 activity. Furthermore, Ruthenium Red, although an inhibitor of mitochondrial calcium uptake, can trigger mechanisms that attempt to compensate for this inhibition, potentially spurring SCaMC-1 into action.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcimycin is an ionophore that promotes calcium influx. By elevating cytosolic calcium levels, it can promote the activity of SCaMC-1, enhancing calcium transport into mitochondria. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator. Elevated calcium levels can stimulate SCaMC-1 to transport more calcium into mitochondria. By transiently chelating calcium, subsequent release can indirectly activate SCaMC-1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca^2+-ATPase (SERCA), leading to increased cytosolic calcium, thereby potentially activating SCaMC-1. | ||||||
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine modulates ryanodine receptors leading to increased cytosolic calcium, which in turn can promote the activity of SCaMC-1. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is an L-type calcium channel blocker. By modulating calcium levels, it can indirectly influence SCaMC-1's calcium transport activity. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $188.00 $250.00 | 13 | |
Ruthenium Red inhibits mitochondrial calcium uptake. Its presence can stimulate compensatory mechanisms, potentially enhancing SCaMC-1 activity. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine can modulate calcium channels, leading to alterations in cytosolic calcium levels, which can influence SCaMC-1 activity. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore, which promotes calcium influx into the cytosol, potentially activating SCaMC-1. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is an L-type calcium channel blocker, and by modulating calcium levels, it can indirectly influence SCaMC-1's calcium transport activity. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, leading to alterations in cytosolic calcium which can subsequently influence SCaMC-1 activity. | ||||||