SBK2 Activators
SBK2 activators are a diverse group of chemical compounds that share the common feature of enhancing the activity of Serine/threonine-protein kinase SBK2, a protein kinase that plays a pivotal role in cellular signaling pathways. These activators are not a homogenous chemical class but are instead characterized by their functional capacity to increase the enzymatic action of SBK2. The mechanisms by which these molecules exert their effects are varied, involving different molecular targets and pathways within the cell. Some compounds, such as forskolin and its derivatives, act by directly stimulating adenylate cyclase, which catalyzes the conversion of ATP to cyclic AMP (cAMP). The increase in cAMP levels leads to the activation of Protein Kinase A (PKA), a key enzyme that can phosphorylate a wide range of substrates, including SBK2, thereby enhancing its kinase activity.
Other SBK2 activators work through alternate cellular mechanisms. For example, compounds like Phorbol 12-myristate 13-acetate (PMA) activate Protein Kinase C (PKC), which can then modulate the activity of various serine/threonine kinases, potentially including SBK2. Similarly, inhibitors of protein phosphatases such as Okadaic Acid and Calyculin A prevent the dephosphorylation of proteins, leading to a sustained activation state of protein kinases that could affect SBK2 activity. Some activators, such as Lithium Chloride, exert their influence by inhibiting other kinases like Glycogen Synthase Kinase 3 (GSK-3), resulting in a downstream enhancement of serine/threonine kinase activity. Additionally, compounds such as Sphingosine-1-phosphate (S1P) may activate sphingosine kinase, which is implicated in the activation of a range of protein kinases, suggesting a possible indirect route to SBK2 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA (protein kinase A), which can then phosphorylate and enhance the activity of Serine/threonine-protein kinase SBK2, as SBK2 is a kinase that can be regulated by phosphorylation. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
As a cAMP analog, 8-Br-cAMP activates PKA, a kinase that can phosphorylate and thereby enhance the activity of various downstream kinases, including Serine/threonine-protein kinase SBK2. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol, a beta-adrenergic agonist, binds to and activates beta-adrenergic receptors, leading to increased intracellular levels of cAMP and activation of PKA, which subsequently can phosphorylate and enhance the activity of SBK2. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits phosphodiesterases, which leads to an accumulation of cAMP in the cell. This increase can activate PKA, and PKA can then phosphorylate and enhance the activity of SBK2. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can also activate stress-activated protein kinases, such as JNKs, which have been known to phosphorylate and activate certain serine/threonine kinases, potentially including SBK2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which in turn can phosphorylate and activate a variety of serine/threonine kinases that could include SBK2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, preventing dephosphorylation of proteins. This can lead to a sustained activation state of protein kinases, including potentially SBK2. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits glycogen synthase kinase 3 (GSK-3), which can result in enhanced activity of downstream serine/threonine kinases through reduced inhibitory phosphorylation, potentially enhancing the activity of SBK2. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
dbcAMP is a cell-permeable cAMP analog that activates PKA, which can lead to the phosphorylation and activation of downstream serine/threonine kinases, potentially including SBK2. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P can activate sphingosine kinase, which has been implicated in the activation of various protein kinases, potentially leading to the activation of SBK2. | ||||||