Chemical inhibitors of SAP 114 contribute to the functional inhibition of its role in the cell cycle, particularly during mitosis. Paclitaxel (Taxol), a well-known microtubule stabilizer, inhibits the function of SAP 114 by maintaining the microtubule structure, which can prevent the dynamic changes required for spindle checkpoint operations and chromosome segregation. Similarly, Vinblastine and Nocodazole disrupt microtubule formation, which is a critical component of the mitotic spindle that SAP 114 is involved with, leading to an inhibition of its function in cell division. Colchicine and Podophyllotoxin also target tubulin to impede microtubule polymerization; this disruption of the mitotic spindle directly inhibits the role of SAP 114 in chromosome segregation. All these chemicals interfere with the microtubule dynamics that are necessary for SAP 114 to perform its role in the spindle assembly checkpoint.
Further targeting the mitotic process, chemicals like Monastrol and S-Trityl-L-cysteine specifically inhibit kinesin motor proteins such as Eg5, which are essential for centrosome separation and spindle pole assembly, both of which are processes where SAP 114 is critical. The inhibition of these kinesin motor proteins by Monastrol and S-Trityl-L-cysteine can therefore impede SAP 114's function in mitosis. Cyclin-dependent kinase inhibitors like Purvalanol A and Roscovitine can inhibit phosphorylation events that SAP 114 requires to control progression through the cell cycle. BI 2536 and Alisertib target PLK1 and Aurora A kinase, respectively; these kinases are pivotal for mitotic progression, centrosome maturation, and separation, as well as spindle assembly. Inhibiting these kinases can therefore inhibit the function of SAP 114 in ensuring accurate chromosome alignment and segregation. ZM447439 further inhibits Aurora kinases, which are involved in the phosphorylation of proteins needed for mitotic spindle function, thus affecting SAP 114's role in the cell cycle.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and as SAP 114 is involved in spindle checkpoint and chromosome segregation during mitosis, stabilization of microtubules can lead to the inhibition of SAP 114's function in cell cycle progression. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine binds to tubulin and inhibits microtubule formation. Since SAP 114 is part of the spindle assembly checkpoint, disruption of microtubule dynamics can lead to inhibition of SAP 114's role in mitotic progression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. By altering microtubule dynamics, it can inhibit the function of SAP 114 in the spindle assembly checkpoint during cell division. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, preventing microtubule polymerization. This action can inhibit SAP 114 by disrupting the mitotic spindle formation and hence its role in chromosome segregation. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization. Through this action, it can inhibit SAP 114's function in the spindle assembly and proper chromosome segregation during mitosis. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol is a kinesin Eg5 inhibitor. It prevents centrosome separation, thereby potentially inhibiting SAP 114's function in the formation of the bipolar spindle apparatus during mitosis. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
Purvalanol A is a cyclin-dependent kinase inhibitor. By inhibiting CDKs, it can inhibit phosphorylation events necessary for mitotic progression, thus affecting SAP 114's function in the cell cycle. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine inhibits cyclin-dependent kinases. Through this inhibition, it can affect the phosphorylation state of proteins involved in mitosis, thereby inhibiting SAP 114's function in cell cycle control. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $148.00 $515.00 | 8 | |
BI 2536 is a PLK1 inhibitor. Inhibiting PLK1 can lead to disruption of mitotic progression and spindle assembly, which are processes where SAP 114 is involved, thus inhibiting its function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor. By inhibiting these kinases, it can interfere with the phosphorylation of proteins required for proper mitotic spindle function, thereby inhibiting SAP 114's role in chromosome alignment and segregation. |