SAHH-3 Activators
SAHH-3 Activators are a collection of chemical compounds that synergize with the biochemical pathways essential for the activation and function of SAHH-3. Adenosine directly contributes to SAHH-3 activation by acting as a substrate, which SAHH-3 converts into inosine and homocysteine, thereby promoting its enzyme catalytic activity. Methionine serves as a precursor in the methylation cycle, ultimately providing S-adenosylhomocysteine (SAH), the substrate for SAHH-3, thus indirectly maintaining the enzyme's activity. Similarly, NAD+ enhances SAHH-3 activity by contributing to the cellular redox state necessary for its catalytic function, while Folic Acid and Vitamin B12 are crucial for one-carbon metabolism, indirectly supporting the generation of SAHH-3 substrates through the remethylation of homocysteine to methionine. Betaine and Choline are methyl donors that support this remethylation process, which is fundamental for the substrate availability of SAHH-3, with Choline being metabolized to betaine which in turn helps to convert homocysteine to methionine.
Furthermore, Riboflavin indirectly supports SAHH-3's activity as a component of the FAD coenzyme, crucial for the regeneration of methionine from homocysteine, while Pyridoxal phosphate (Vitamin B6) influences SAHH-3 activity by modulating the levels of homocysteine and cysteine through its role as a cofactor in the transsulfuration pathway. Zinc, as a cofactor for the synthesis of methionine, indirectly impacts SAHH-3 by ensuring the production of its substrates, crucial for the enzyme's function. Spermidine also plays a role in indirectly maintaining SAHH-3's activity by influencing the methylation process and the regeneration of SAH, which is essential for the growth and function of cells. Lastly, Magnesium is key for the activity of enzymes in the one-carbon pathway, including methionine synthase, and its presence is vital for the bioavailability of SAHH-3 substrates, thus indirectly influencing the enzyme's functional capacity. These SAHH-3 activators, through their targeted effects on metabolic pathways and substrate availability, ensure the enhancement of SAHH-3's enzymatic action without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine naturally increases the activity of SAHH-3 by serving as a substrate for the hydrolytic reaction SAHH-3 catalyzes, which converts adenosine and S-adenosylhomocysteine to inosine and homocysteine, respectively. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine influences the SAHH-3 pathway by serving as a precursor to S-adenosylmethionine (SAM), which is then demethylated to S-adenosylhomocysteine (SAH), the substrate for SAHH-3. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor in redox reactions that can indirectly enhance SAHH-3 activity by maintaining cellular redox state, which is necessary for the proper catalytic function of SAHH-3. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Folic acid participates in the one-carbon metabolism pathway, indirectly supporting the generation of substrates for SAHH-3 by aiding in the remethylation of homocysteine to methionine, which is then converted to SAH. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Vitamin B12 is involved in the remethylation of homocysteine to methionine, indirectly supporting SAHH-3 activity by maintaining the pool of methionine, a precursor to SAH. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Betaine donates a methyl group in the liver and kidneys for the conversion of homocysteine to methionine, indirectly maintaining the substrate availability for SAHH-3. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline can be oxidized to betaine, which in turn participates in homocysteine remethylation, indirectly supporting SAHH-3 by ensuring the methionine, and thus SAH, supply. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin, as a component of the FAD coenzyme, is essential for the methionine synthase enzyme that regenerates methionine from homocysteine, indirectly supporting SAHH-3's activity by maintaining its substrate supply. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
Pyridoxal phosphate is a cofactor for cystathionine β-synthase and cystathionine γ-lyase in the transsulfuration pathway, indirectly influencing SAHH-3 activity by modulating levels of homocysteine and cysteine. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for numerous enzymes, including those involved in the synthesis of methionine, and can indirectly enhance SAHH-3 activity by ensuring the production of its substrates. | ||||||