RYD5 Inhibitors
Chemical inhibitors of RYD5 can modulate the protein's function through various mechanisms by targeting specific pathways and enzymatic activities. Staurosporine, a broad-spectrum protein kinase inhibitor, can hinder RYD5 if it is a kinase or relies on phosphorylation processes. By competing with ATP binding sites, staurosporine can prevent phosphorylation events essential for RYD5's catalytic action. Similarly, if RYD5 is associated with the PI3K/Akt pathway, LY294002 can act as a specific inhibitor, blocking PI3K and disrupting any subsequent activation of RYD5. PD98059 and U0126 both target the MAPK/ERK pathway at different points; PD98059 inhibits MEK, which is upstream of ERK, while U0126 selectively inhibits MEK1/2. If RYD5 operates downstream or is regulated by this pathway, these inhibitors can suppress its activation by obstructing the upstream signals.
Rapamycin specifically inhibits mTOR, which could affect RYD5 if its activity is tied to mTOR's role in cell growth and metabolism. Conversely, SB431542 targets the TGF-beta receptor, which would impact RYD5 if it is part of or regulated by the TGF-beta signaling pathway. Wortmannin and PP2 offer a means to inhibit RYD5 through their action on PI3K and Src family tyrosine kinases, respectively, preventing activation of RYD5 by these upstream kinases. SP600125, an inhibitor of JNK, could impede RYD5 if JNK signaling regulates it. Bortezomib's proteasome inhibition mechanism suggests a different approach, potentially leading to the accumulation of RYD5 if it is normally regulated through proteasomal degradation. Y-27632 and gefitinib, by inhibiting ROCK and EGFR tyrosine kinase respectively, can interfere with RYD5 if it is involved in the pathways regulated by these enzymes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. If RYD5 is a kinase or associated with phosphorylation, staurosporine can inhibit its activity by preventing ATP binding and phosphorylation events that RYD5 might catalyze or depend on. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. If RYD5 is involved in the PI3K/Akt pathway, LY294002 can inhibit this pathway, resulting in the functional inhibition of downstream proteins including RYD5 if it is part of this signaling cascade. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a specific inhibitor of MEK, which acts upstream of ERK in the MAPK pathway. If RYD5 functions downstream of or is regulated by the MAPK pathway, inhibition by PD98059 can prevent its activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically inhibits mTOR, a central protein in regulating cell growth and metabolism. If RYD5 activity is linked to mTOR signaling, rapamycin can inhibit RYD5 by inhibiting mTOR activity. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
SB431542 is an inhibitor of the TGF-beta receptor. If RYD5 is involved in the TGF-beta signaling pathway, SB431542 can inhibit the signaling pathway, thus inhibiting the function of RYD5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of phosphoinositide 3-kinases. If RYD5 is activated by PI3K signaling, wortmannin can inhibit RYD5 by preventing PI3K-mediated signaling events. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase). If RYD5 is a target of JNK or if its activity is modulated by JNK signaling, SP600125 can inhibit RYD5 by inhibiting JNK activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream of ERK. If RYD5 functions downstream of or is regulated by the ERK pathway, U0126 can inhibit the activation of RYD5 by inhibiting MEK activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. If RYD5 is regulated by proteasomal degradation, bortezomib can inhibit its function by preventing its degradation, leading to a functional inhibition due to the accumulation of non-functional or misfolded proteins. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is an inhibitor of ROCK (Rho-associated protein kinase). If RYD5 is involved in the Rho/ROCK pathway, Y-27632 can inhibit RYD5 by inhibiting ROCK and thus the signaling pathway that would activate RYD5. | ||||||