Date published: 2026-5-30

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Rrp6 Inhibitors

Rrp6 inhibitors represent a class of chemical compounds designed to selectively target and modulate the activity of the Rrp6 protein. Rrp6, also known as Rat1 in yeast, is an essential component of the RNA exosome complex, which is responsible for RNA processing and degradation in eukaryotic cells. This protein complex plays a crucial role in maintaining RNA quality control, regulating the turnover of various RNA species, including ribosomal RNA (rRNA), messenger RNA (mRNA), and small non-coding RNAs. Rrp6 inhibitors serve as invaluable tools in molecular biology and cellular research, allowing scientists to investigate the intricate roles of Rrp6 in RNA metabolism and the mechanisms underlying RNA processing and degradation.

Researchers use Rrp6 inhibitors to explore the specific functions of Rrp6 within the RNA exosome complex. By selectively inhibiting Rrp6, scientists can examine its interactions with other exosome components, its role in RNA degradation pathways, and its contributions to the surveillance and quality control of RNA molecules. This research aids in unraveling the molecular processes that govern the stability and turnover of various RNA species, ultimately contributing to our understanding of gene expression regulation and the maintenance of cellular RNA homeostasis. Additionally, the study of Rrp6 inhibitors has broader implications for elucidating the mechanisms of RNA processing and turnover in eukaryotic cells, offering insights into the complex network of pathways that shape the RNA landscape and its impact on cellular functions. In summary, Rrp6 inhibitors serve as essential tools for unraveling the molecular intricacies of RNA metabolism and RNA quality control, enhancing our understanding of cellular processes related to gene expression and RNA stability.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$74.00
$243.00
$731.00
$2572.00
$21848.00
53
(3)

This compound intercalates into DNA and prevents RNA synthesis by RNA polymerase, potentially leading to reduced Rrp6 expression.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$269.00
$1050.00
26
(2)

A potent inhibitor of RNA polymerase II; it could decrease transcription levels of Rrp6 mRNA.

Rifampicin

13292-46-1sc-200910
sc-200910A
sc-200910B
sc-200910C
1 g
5 g
100 g
250 g
$97.00
$328.00
$676.00
$1467.00
6
(1)

Known to inhibit bacterial RNA polymerase; in eukaryotes, it might influence RNA pol I and III, indirectly affecting Rrp6 levels.

Triptolide

38748-32-2sc-200122
sc-200122A
1 mg
5 mg
$90.00
$204.00
13
(1)

It inhibits transcriptional activity by affecting RNA polymerase II, possibly reducing Rrp6 mRNA synthesis.

Cordycepin

73-03-0sc-203902
10 mg
$101.00
5
(1)

Cordycepin is an adenosine analog that disrupts RNA synthesis and could lead to decreased levels of Rrp6 mRNA.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$43.00
$189.00
$316.00
$663.00
6
(1)

DRB inhibits RNA polymerase II phosphorylation, potentially reducing Rrp6 expression.

Leptomycin B

87081-35-4sc-358688
sc-358688A
sc-358688B
50 µg
500 µg
2.5 mg
$107.00
$416.00
$1248.00
35
(2)

This compound inhibits nuclear export, which could lead to indirect effects on Rrp6 mRNA levels and stability.

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$69.00
$266.00
8
(1)

By depleting guanine nucleotides, this compound could indirectly reduce transcription of Rrp6.

Fluorouracil

51-21-8sc-29060
sc-29060A
1 g
5 g
$37.00
$152.00
11
(1)

As a nucleotide analog, it may incorporate into RNA, potentially affecting Rrp6 mRNA stability and levels.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$41.00
$84.00
$275.00
127
(6)

Inhibits eukaryotic protein synthesis, potentially leading to a decrease in Rrp6 protein levels indirectly by blocking translation.