RPA16 Inhibitors
RPA16 inhibitors constitute a group within the larger chemical landscape that specifically target a protein often denoted as RPA16. RPA16 is an abbreviation for Replication Protein A 16 kDa subunit, which is a component of a protein complex known for its crucial role in DNA processes. The RPA complex, which includes RPA16, is involved in various cellular activities including DNA replication, repair, and recombination. RPA16 inhibitors are designed to interact with the RPA16 subunit in a way that affects its function. These inhibitors are typically small molecules that can bind to the RPA16 protein, potentially altering its conformation or steric properties, and thus modulating its activity within the cell.
The development and study of RPA16 inhibitors revolve around understanding the protein's structure and dynamics, as well as the biochemical pathways it participates in. By targeting RPA16, these inhibitors can influence the protein-protein interactions and the binding affinity of RPA to DNA, which are essential for its role in DNA metabolism. The precise mechanism of inhibition can vary among different RPA16 inhibitors, depending on their structure and the specific site of the RPA16 subunit they bind to
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Binds DNA at the transcription initiation complex, inhibiting RNA synthesis. This can indirectly reduce POLR1D's role in the RNA polymerase I complex. | ||||||
CX-5461 | 1138549-36-6 | sc-507275 | 5 mg | $245.00 | ||
Inhibits rRNA synthesis by blocking RNA polymerase I transcription. Affects POLR1D function as part of the RNA polymerase I complex. | ||||||
BMH-21 | 896705-16-1 | sc-507460 | 10 mg | $165.00 | ||
Binds to GC-rich sequences and selectively inhibits RNA polymerase I. Can affect POLR1D's activity by halting the RNA polymerase I complex. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA polymerases, including RNA polymerase I. Can hamper POLR1D's role in RNA polymerase I-mediated transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Binds DNA and interferes with transcription by RNA polymerase I, II, and III. This binding affects POLR1D's function in the RNA polymerase I complex. | ||||||
Acivicin | 42228-92-2 | sc-200498B sc-200498C sc-200498 sc-200498D | 1 mg 5 mg 10 mg 25 mg | $104.00 $416.00 $655.00 $1301.00 | 10 | |
By affecting glutamine metabolism, it impacts nucleotide synthesis and hence RNA synthesis, indirectly impacting POLR1D function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
DNA topoisomerase I inhibitor. While its primary target isn't POLR1D, by affecting DNA topology and transcription processes, it can indirectly impact POLR1D's role. | ||||||
Thiolutin | 87-11-6 | sc-200387 sc-200387A | 1 mg 5 mg | $101.00 $406.00 | 1 | |
Known to inhibit RNA polymerases and thus can have an effect on POLR1D's function in the RNA polymerase I complex. | ||||||