Camptothecin CAS: 7689-03-4
MF: C20H16N2O4
MW: 348.4
A reversible Mitochondrial Topo I inhibitor shown to exhibit antitumor activity.

Camptothecin (CAS 7689-03-4)

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同义词: (S)-(+)-Camptothecin
应用; A reversible Mitochondrial Topo I inhibitor shown to exhibit antitumor activity
CAS号码: 7689-03-4
纯度: ≥98%
分子量: 348.4
分子式: C20H16N2O4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 参考分析证明 大量特定数据 (包括水 含量).
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Camptothecin was originally isolated from the stem wood of the Camptotheca acuminata tree and was shown to exhibit antileukemic/antitumor activity, and reversibly inhibit Mitochondrial Topo I (nuclear Topo I (topoisomerase I)) by binding to and stabilizing the topoisomerase-DNA covalent complex. Advancing replication forks are believed to interact with these complexes leading to double strand breaks, which is thought to be responsible for much of the cytotoxicity; other research has shown that some of the antitumor activity could be derived from the inhibition of NOS2 (iNOS or inducible nitric oxide synthase) which generates nitric oxide, an important regulator of angiogenesis and other biochemical pathways. The discovery of camptothecin spurred the development of many derivatives with superior activity and solubility, including irinotecan (sc-202186) and topotecan (sc-204919). Although most noted for its anticancer activity, camptothecin and derivatives have shown other pertinent biochemical actions, including: antiprotozoal, antimalarial, inhibition of HIV, upregulation of p53, and induction of apoptosis. This product also exhibits intense blue fluorescence when exposed to UV light, which could be useful in optical experiments.


参考文献

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6. Shimizu, T., et al. 1997. Leukemia. 11: 1238-1244. PMID: 9264376
7. Pommier, Y., et al. 1998. Biochim. Biophys. Acta. 1400: 83-105. PMID: 9748515
8. Chiou, W.F., et al. 2001. Life Sci. 69: 625-635. PMID: 11476184
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物理状态 :
Solid
溶解度 :
Soluble in chloroform/methanol (4:1) (4 mg/ml), DMSO (10 mg/ml), methanol (40 mg/ml), 0.1N sodium hydroxide (50 mg/ml), and acetic acid. Insoluble in water.
保存 :
Store at -20° C
熔点 :
260° C (dec.)
折射率 :
n20D 1.75
IC50 :
DNA enzyme topoisomerase I (topo I): IC50 = 0.68 µM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
UQ0492000
PubChem CID :
24360
默克索引 :
14: 1735
MDL 号码 :
MFCD00081076
Beilstein 注册 :
631069
SMILES :
CC[[email protected]@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

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PMID: # 17030995  Malavazi, I. et al. 2006. Eukaryotic Cell. 5: 1688-1704.

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