Molecular structure of BMH-21, CAS Number: 896705-16-1
BMH-21 (CAS 896705-16-1)
Alternate Names:
N-[2-(dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide
CAS Number:
896705-16-1
Molecular Weight:
360.4
Molecular Formula:
C21H20N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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BMH-21 (CAS 896705-16-1) References
- DNA intercalator BMH-21 inhibits RNA polymerase I independent of DNA damage response. | Colis, L., et al. 2014. Oncotarget. 5: 4361-9. PMID: 24952786
- BMH-21 inhibits viability and induces apoptosis by p53-dependent nucleolar stress responses in SKOV3 ovarian cancer cells. | Fu, X., et al. 2017. Oncol Rep. 38: 859-865. PMID: 28656213
- c-MYC G-quadruplex binding by the RNA polymerase I inhibitor BMH-21 and analogues revealed by a combined NMR and biochemical Approach. | Musso, L., et al. 2018. Biochim Biophys Acta Gen Subj. 1862: 615-629. PMID: 29229300
- Stabilization of c-KIT G-Quadruplex DNA Structures by the RNA Polymerase I Inhibitors BMH-21 and BA-41. | Mazzini, S., et al. 2019. Int J Mol Sci. 20: PMID: 31590335
- Nucleolar translocation of human DNA topoisomerase II by ATP depletion and its disruption by the RNA polymerase I inhibitor BMH-21. | Morotomi-Yano, K. and Yano, KI. 2021. Sci Rep. 11: 21533. PMID: 34728715
- The small-molecule BMH-21 directly inhibits transcription elongation and DNA occupancy of RNA polymerase I in vivo and in vitro. | Jacobs, RQ., et al. 2022. J Biol Chem. 298: 101450. PMID: 34838819
- RNA Polymerase I Is Uniquely Vulnerable to the Small-Molecule Inhibitor BMH-21. | Jacobs, RQ., et al. 2022. Cancers (Basel). 14: PMID: 36428638
- Transcription elongation mechanisms of RNA polymerases I, II, and III and their therapeutic implications. | Jacobs, RQ. and Schneider, DA. 2024. J Biol Chem. 300: 105737. PMID: 38336292
- Chromatin damage generated by DNA intercalators leads to degradation of RNA Polymerase II. | Espinoza, JA., et al. 2024. Nucleic Acids Res. 52: 4151-4166. PMID: 38340348
- DNA-PK participates in pre-rRNA biogenesis independent of DNA double-strand break repair. | Li, P., et al. 2024. Nucleic Acids Res. 52: 6360-6375. PMID: 38682589
Inhibitor of:
9130206N08Rik, BRF2, BXDC1, C20orf112, CGI-96, D130037M23Rik, DDX27, ESF1, EXOSC5, Glycophorin C, hPMS1, KIAA0391, KRR1, LARP7, LAS1L, LOC345630, LOC644192, LSm12, LTV1, MPP10, mrnp41, MRT4, Mxi1, NHP2, NHPX, NIP7, NMD3, NOL8, Nop10, NOP9, Nucleostemin, NVL, p54/nrb, Pcdbh6, Pcdhb18, Pol I, Pol II RPB6, Pol III RPC39, POLR3E, POLR3GL, POLR3H, POLR3K, RBM15, RBM7, Ribosomal Protein L10a, Ribosomal Protein L11, RNA pol σ F, RPA135, RPA16, RPA194, RPAIN, Rpb4, Rpb7, RRP7A, RRP9, RSL24D1, SNX17, SUV3, TERC, TFIIF RAP 30, TFIIIB90, TFIIIC90, UTP11L, UTP23, Vmn2r112, Vmn2r63, WDR74, ZCCHC8, and ZNF593.Activator of:
BMS1, DDX28, Exportin T, FBL16, Josephin-3, Nop14, POLR1E, Ribosomal Protein L26L1, SURF-6, TIAR, and WDR12.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMH-21, 10 mg | sc-507460 | 10 mg | $165.00 |