Acivicin CAS: 42228-92-2
MF: C5H7ClN2O3
MW: 178.57
An inhibitor of GGT used for solid tumor research.

Acivicin (CAS 42228-92-2)

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备用名: αS-amino-3-chloro-4,5S-dihydro-5-isoxazoleacetic acid; (αS,5S)-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid; [S-(R*,R*)]-α-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic Acid; AT 125; Antibiotic AT 125; NSC 163501; U 42126; (+)-Acivicin
应用; Acivicin is an inhibitor of GGT used for solid tumor research
CAS号码: 42228-92-2
纯度: ≥97%
分子量: 178.57
分子式: C5H7ClN2O3
补充资料: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
仅供科研使用。不可用于诊断或治疗。
* 参考分析证明 大量特定数据 (包括水 含量).

Acivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been administered for research in a variety of solid tumors. Bone marrow depression and central neurotoxicity has been observed to suggest that it may be dose-limiting. Acivicin is an irreversible inhibitor of GGT (γ-glutamyl transpeptidase) ID50 = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, the product displays anti tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.


参考文献

1. Allen, L., et al. 1980. Res. Commun. Chem. Pathol. Pharmacol. 27: 175-185. PMID: 6102405
2. Griffith, O.W., et al. 1980. Proc. Natl. Acad. Sci. U.S.A. 77: 3384-3387. PMID: 6106190
3. Ruoso, P., et al. 2004. Cancer Chemother. Pharmacol. 54: 49-56. PMID: 15034755
4. Obrador, E., et al. 2002. Hepatology. 35: 74-81. PMID: 11786961
5. Schmees, C., et al. 2007. Gastroenterology. 132: 1820-1833. PMID: 17484877
6. Hogg, N., et al. 1997. Biochem. J. 323: 477-481. PMID: 9163341

物理状态 :
Solid
溶解度 :
Soluble in water (18 mg/mL, max), and 1 N HCl (50 mg/mL, with heat as needed).
保存 :
Store at -20° C
熔点 :
209-211° C
沸点 :
~341.6° C at 760 mmHg (Predicted)
密度 :
~1.9 g/cm3 (Predicted)
折射率 :
n20D 1.66
IC50 :
HIV-1(RF): IC50 = > 15.2 uM
仅供科研使用。不可用于诊断或治疗。
德国水公害等级 :
3
RTECS :
NY2103000
PubChem CID :
MDL 号码 :
MFCD00058450
SMILES :
C1[[email protected]](ON=C1Cl)[[email protected]@H](C(=O)O)N

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PMID: # 25909891  Jimenez-Blasco, D. et al. 2015. Cell Death Differ. 22: 1877-89.

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PMID: # 23012257  Bowens, NH. et al. 2013. Molecular pharmacology. 83: 22-32.

PMID: # 23382221  Oertli, M. et al. 2013. Proceedings of the National Academy of Sciences of the United States of America. 110: 3047-52.

PMID: # 22052286  Fuentealba, RA. et al. 2012. Human molecular genetics. 21: 664-80.

PMID: # 16183645  Diaz-Hernandez, JI. et al. 2005. J. Biol. Chem. 280: 38992-39001.

PMID: # 15716335  Solbu, TT. et al. 2005. J. Am. Soc. Nephrol. 16: 869-877.

PMID: # 32284594  Nat. Immunol.

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