Rotavirus capsid Inhibitors

Chemical inhibitors of the rotavirus capsid encompass a diverse range of compounds that potentially influence the virus's life cycle, including its entry, replication, and maturation within host cells. The first group of inhibitors includes antiviral agents and compounds that interfere with viral replication mechanisms. Ribavirin, a nucleoside analog, can inhibit rotavirus replication by interfering with the synthesis of viral RNA. Similarly, Nitazoxanide, an antiprotozoal agent, may disrupt the replication and assembly of the virus within host cells. Polyphenols like Epigallocatechin gallate (EGCG) and compounds such as Zinc acetate and Rupintrivir could interfere with various stages of the viral lifecycle, including entry, replication, and maturation.

The second group of compounds includes agents that influence the host environment and immune response to impede the virus's ability to infect and replicate. Bismuth subsalicylate and Ursodeoxycholic acid can alter the gastrointestinal environment, potentially affecting rotavirus survival and replication. Lactoferrin, found in milk, may disrupt the virus's binding and entry into host cells. Nitric oxide and Curcumin can modulate the host immune response, thereby affecting the virus's ability to establish and maintain infection. Silymarin and Oseltamivir, although not directly targeting rotavirus, may have indirect effects on its lifecycle through modulation of host cell pathways and immune responses.