Oseltamivir Phosphate is an active (orally) inhibitor of the influenze virus neuraminidase and converted to the active acid metabolite in vivo. Also demonstrates antiviral drug capabilities.
Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998), Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998), Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999), Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)
Soluble in water (>500 mg/ml), methanol, DMSO (2 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Store at -20° C
n20D 1.50 (Predicted)
Influenza A virus: IC50 = 1.1 µM
pKa: 7.7 at 25° C in primary amine
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Hrynyk et alHrynyk et al. (PubMed ID 26309402) found that oseltamivir phosphate-loaded PLGA implants surgically inserted into sites of solid tumor reduce the likelihood of metastasis in a mice model of human pancreatic carcinoma. -SCBT Publication Review
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