RNF175 Activators
RNF175 activators are chemicals that indirectly interact with and activate the cellular and biochemical pathways associated with the RING finger protein 175 (RNF175). These compounds generally exert their effects through the modulation of ubiquitination pathways or the proteasome, a complex responsible for protein degradation, which could enhance the functional activity of RNF175 in tagging proteins for degradation.
Proteasome inhibitors like Withaferin A, Epoxomicin, and Bortezomib may contribute to the accumulation of ubiquitinated proteins, thereby possibly stimulating the activity of RNF175 to manage this buildup. Inhibitors of NF-κB, including PDTC, Piceatannol, TPCA-1, and Parthenolide, might alter the inflammatory response, which could also modify the ubiquitination landscape in which RNF175 operates. Additionally, compounds such as Triterpenoid CDDO, by influencing the ubiquitin ligase system, may indirectly necessitate increased RNF175 activity. Lastly, β-Lapachone, through its effect on cellular redox states, may invoke broader regulatory changes in cellular signaling, indirectly modulating RNF175 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $33.00 $64.00 | 11 | |
NF-κB inhibitor that can modulate inflammatory responses, potentially increasing the demand for RNF175's activity in protein regulation. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Natural inhibitor of the proteasome, leading to accumulation of ubiquitinated proteins, which may indirectly enhance RNF175's activity. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Inhibits NF-κB activation, potentially altering the ubiquitination landscape and influencing RNF175's activity. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
Inhibitor of IKK-2 involved in NF-κB activation, could indirectly enhance the requirement for RNF175-mediated ubiquitination in immune responses. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
NF-κB pathway inhibitor that may indirectly increase the ubiquitination processes RNF175 is involved in. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
A selective proteasome inhibitor, potentially increasing ubiquitinated protein levels and indirectly enhancing RNF175 activity. | ||||||
CDDO Methyl Ester | 218600-53-4 | sc-504720 | 10 mg | $220.00 | ||
Modulates various signaling pathways including the ubiquitin-proteasome system, potentially affecting RNF175's role. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $112.00 $459.00 | 8 | |
Via NQO1-mediated pathways, influences the cellular redox state, which can modulate various signaling pathways including those associated with RNF175. | ||||||